Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System

Stromal connective tissue contains mesenchymal cells, including fibroblasts and myofibroblasts, which line the tissue structure. However, it has been identified that the function of mesenchymal cells is not just structural—they also play critical roles in the creation and regulation of intestinal ho...

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Autores principales: Kurashima, Yosuke, Yamamoto, Daiki, Nelson, Sean, Uematsu, Satoshi, Ernst, Peter B., Nakayama, Toshinori, Kiyono, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733542/
https://www.ncbi.nlm.nih.gov/pubmed/29321781
http://dx.doi.org/10.3389/fimmu.2017.01787
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author Kurashima, Yosuke
Yamamoto, Daiki
Nelson, Sean
Uematsu, Satoshi
Ernst, Peter B.
Nakayama, Toshinori
Kiyono, Hiroshi
author_facet Kurashima, Yosuke
Yamamoto, Daiki
Nelson, Sean
Uematsu, Satoshi
Ernst, Peter B.
Nakayama, Toshinori
Kiyono, Hiroshi
author_sort Kurashima, Yosuke
collection PubMed
description Stromal connective tissue contains mesenchymal cells, including fibroblasts and myofibroblasts, which line the tissue structure. However, it has been identified that the function of mesenchymal cells is not just structural—they also play critical roles in the creation and regulation of intestinal homeostasis. Thus, mucosal mesenchymal cells instruct intestinal immune cell education (or peripheral immune education) and epithelial cell differentiation thereby shaping the local environment of the mucosal immune system. Malfunction of the mesenchymal cell-mediated instruction system (e.g., fibrosis) leads to pathological conditions such as intestinal stricture.
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spelling pubmed-57335422018-01-10 Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System Kurashima, Yosuke Yamamoto, Daiki Nelson, Sean Uematsu, Satoshi Ernst, Peter B. Nakayama, Toshinori Kiyono, Hiroshi Front Immunol Immunology Stromal connective tissue contains mesenchymal cells, including fibroblasts and myofibroblasts, which line the tissue structure. However, it has been identified that the function of mesenchymal cells is not just structural—they also play critical roles in the creation and regulation of intestinal homeostasis. Thus, mucosal mesenchymal cells instruct intestinal immune cell education (or peripheral immune education) and epithelial cell differentiation thereby shaping the local environment of the mucosal immune system. Malfunction of the mesenchymal cell-mediated instruction system (e.g., fibrosis) leads to pathological conditions such as intestinal stricture. Frontiers Media S.A. 2017-12-13 /pmc/articles/PMC5733542/ /pubmed/29321781 http://dx.doi.org/10.3389/fimmu.2017.01787 Text en Copyright © 2017 Kurashima, Yamamoto, Nelson, Uematsu, Ernst, Nakayama and Kiyono. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kurashima, Yosuke
Yamamoto, Daiki
Nelson, Sean
Uematsu, Satoshi
Ernst, Peter B.
Nakayama, Toshinori
Kiyono, Hiroshi
Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System
title Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System
title_full Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System
title_fullStr Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System
title_full_unstemmed Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System
title_short Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System
title_sort mucosal mesenchymal cells: secondary barrier and peripheral educator for the gut immune system
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733542/
https://www.ncbi.nlm.nih.gov/pubmed/29321781
http://dx.doi.org/10.3389/fimmu.2017.01787
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