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Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors

This article provides a review of the effects of activation of muscarinic and nicotinic receptors on the physiological properties of circuits in the hippocampal formation. Previous articles have described detailed computational hypotheses about the role of cholinergic neuromodulation in enhancing th...

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Detalles Bibliográficos
Autores principales: Dannenberg, Holger, Young, Kimberly, Hasselmo, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733553/
https://www.ncbi.nlm.nih.gov/pubmed/29321728
http://dx.doi.org/10.3389/fncir.2017.00102
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author Dannenberg, Holger
Young, Kimberly
Hasselmo, Michael
author_facet Dannenberg, Holger
Young, Kimberly
Hasselmo, Michael
author_sort Dannenberg, Holger
collection PubMed
description This article provides a review of the effects of activation of muscarinic and nicotinic receptors on the physiological properties of circuits in the hippocampal formation. Previous articles have described detailed computational hypotheses about the role of cholinergic neuromodulation in enhancing the dynamics for encoding in cortical structures and the role of reduced cholinergic modulation in allowing consolidation of previously encoded information. This article will focus on addressing the broad scope of different modulatory effects observed within hippocampal circuits, highlighting the heterogeneity of cholinergic modulation in terms of the physiological effects of activation of muscarinic and nicotinic receptors and the heterogeneity of effects on different subclasses of neurons.
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spelling pubmed-57335532018-01-10 Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors Dannenberg, Holger Young, Kimberly Hasselmo, Michael Front Neural Circuits Neuroscience This article provides a review of the effects of activation of muscarinic and nicotinic receptors on the physiological properties of circuits in the hippocampal formation. Previous articles have described detailed computational hypotheses about the role of cholinergic neuromodulation in enhancing the dynamics for encoding in cortical structures and the role of reduced cholinergic modulation in allowing consolidation of previously encoded information. This article will focus on addressing the broad scope of different modulatory effects observed within hippocampal circuits, highlighting the heterogeneity of cholinergic modulation in terms of the physiological effects of activation of muscarinic and nicotinic receptors and the heterogeneity of effects on different subclasses of neurons. Frontiers Media S.A. 2017-12-13 /pmc/articles/PMC5733553/ /pubmed/29321728 http://dx.doi.org/10.3389/fncir.2017.00102 Text en Copyright © 2017 Dannenberg, Young and Hasselmo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Dannenberg, Holger
Young, Kimberly
Hasselmo, Michael
Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors
title Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors
title_full Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors
title_fullStr Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors
title_full_unstemmed Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors
title_short Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors
title_sort modulation of hippocampal circuits by muscarinic and nicotinic receptors
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733553/
https://www.ncbi.nlm.nih.gov/pubmed/29321728
http://dx.doi.org/10.3389/fncir.2017.00102
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