First-in-Human Treatment With a Dendritic Cell-targeting Lentiviral Vector-expressing NY-ESO-1, LV305, Induces Deep, Durable Response in Refractory Metastatic Synovial Sarcoma Patient

Effective induction of antitumor T cells is a pivotal goal of cancer immunotherapy. To this end, lentiviral vectors (LV) are uniquely poised to directly prime CD8 T-cell responses via transduction of dendritic cells in vivo and have shown promise as active cancer therapeutics in preclinical tumor mo...

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Detalles Bibliográficos
Autores principales: Pollack, Seth M., Lu, Hailing, Gnjatic, Sacha, Somaiah, Neeta, O’Malley, Ryan B., Jones, Robin L., Hsu, Frank J., ter Meulen, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733794/
https://www.ncbi.nlm.nih.gov/pubmed/28891906
http://dx.doi.org/10.1097/CJI.0000000000000183

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