Safety and Tolerability Study of an Intravenously Administered Small Interfering Ribonucleic Acid (siRNA) Post On-Pump Cardiothoracic Surgery in Patients at Risk of Acute Kidney Injury

INTRODUCTION: Patients undergoing on-pump cardiac surgery are at an increased risk of acute kidney injury. QPI-1002, a small interfering ribonucleic acid, is under clinical development for the prevention of acute kidney injury. The safety, tolerability, and pharmacokinetics of QPI-1002 was evaluated...

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Detalles Bibliográficos
Autores principales: Demirjian, Segav, Ailawadi, Gorav, Polinsky, Martin, Bitran, Dani, Silberman, Shuli, Shernan, Stanton Keith, Burnier, Michel, Hamilton, Marta, Squiers, Elizabeth, Erlich, Shai, Rothenstein, Daniel, Khan, Samina, Chawla, Lakhmir S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733816/
https://www.ncbi.nlm.nih.gov/pubmed/29270490
http://dx.doi.org/10.1016/j.ekir.2017.03.016

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