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Association between coffee or caffeine consumption and fecundity and fertility: a systematic review and dose–response meta-analysis
OBJECTIVE: The aim was to investigate whether coffee or caffeine consumption is associated with reproductive endpoints among women with natural fertility (ie, time to pregnancy [TTP] and spontaneous abortion [SAB]) and among women in fertility treatment (ie, clinical pregnancy rate or live birth rat...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733907/ https://www.ncbi.nlm.nih.gov/pubmed/29276412 http://dx.doi.org/10.2147/CLEP.S146496 |
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author | Lyngsø, Julie Ramlau-Hansen, Cecilia Høst Bay, Bjørn Ingerslev, Hans Jakob Hulman, Adam Kesmodel, Ulrik Schiøler |
author_facet | Lyngsø, Julie Ramlau-Hansen, Cecilia Høst Bay, Bjørn Ingerslev, Hans Jakob Hulman, Adam Kesmodel, Ulrik Schiøler |
author_sort | Lyngsø, Julie |
collection | PubMed |
description | OBJECTIVE: The aim was to investigate whether coffee or caffeine consumption is associated with reproductive endpoints among women with natural fertility (ie, time to pregnancy [TTP] and spontaneous abortion [SAB]) and among women in fertility treatment (ie, clinical pregnancy rate or live birth rate). DESIGN: This study was a systematic review and dose–response meta-analysis including data from case–control and cohort studies. METHODS: An extensive literature search was conducted in MEDLINE and Embase, with no time and language restrictions. Also, reference lists were searched manually. Two independent reviewers assessed the manuscript quality using the Newcastle–Ottawa Scale (NOS). A two-stage dose–response meta-analysis was applied to assess a potential association between coffee/caffeine consumption and the outcomes: TTP, SAB, clinical pregnancy, and live birth. Heterogeneity between studies was assessed using Cochrane Q-test and I(2) statistics. Publication bias was assessed using Egger’s regression test. RESULTS: The pooled results showed that coffee/caffeine consumption is associated with a significantly increased risk of SAB for 300 mg caffeine/day (relative risk [RR]: 1.37, 95% confidence interval [95% CI]: 1.19; 1.57) and for 600 mg caffeine/day (RR: 2.32, 95% CI: 1.62; 3.31). No association was found between coffee/caffeine consumption and outcomes of fertility treatment (based on two studies). No clear association was found between exposure to coffee/caffeine and natural fertility as measured by fecundability odds ratio (based on three studies) or waiting TTP (based on two studies). CONCLUSION: Results from this meta-analysis support the growing evidence of an association between coffee/caffeine intake and the risk of SAB. However, viewing the reproductive capacity in a broader perspective, there seems to be little, if any, association between coffee/caffeine consumption and fecundity. In general, results from this study are supportive of a precautionary principle advised by health organizations such as European Food Safety Authority (EFSA) and World Health Organization (WHO), although the advised limit of a maximum of two to three cups of coffee/200–300 mg caffeine per day may be too high. |
format | Online Article Text |
id | pubmed-5733907 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-57339072017-12-22 Association between coffee or caffeine consumption and fecundity and fertility: a systematic review and dose–response meta-analysis Lyngsø, Julie Ramlau-Hansen, Cecilia Høst Bay, Bjørn Ingerslev, Hans Jakob Hulman, Adam Kesmodel, Ulrik Schiøler Clin Epidemiol Review OBJECTIVE: The aim was to investigate whether coffee or caffeine consumption is associated with reproductive endpoints among women with natural fertility (ie, time to pregnancy [TTP] and spontaneous abortion [SAB]) and among women in fertility treatment (ie, clinical pregnancy rate or live birth rate). DESIGN: This study was a systematic review and dose–response meta-analysis including data from case–control and cohort studies. METHODS: An extensive literature search was conducted in MEDLINE and Embase, with no time and language restrictions. Also, reference lists were searched manually. Two independent reviewers assessed the manuscript quality using the Newcastle–Ottawa Scale (NOS). A two-stage dose–response meta-analysis was applied to assess a potential association between coffee/caffeine consumption and the outcomes: TTP, SAB, clinical pregnancy, and live birth. Heterogeneity between studies was assessed using Cochrane Q-test and I(2) statistics. Publication bias was assessed using Egger’s regression test. RESULTS: The pooled results showed that coffee/caffeine consumption is associated with a significantly increased risk of SAB for 300 mg caffeine/day (relative risk [RR]: 1.37, 95% confidence interval [95% CI]: 1.19; 1.57) and for 600 mg caffeine/day (RR: 2.32, 95% CI: 1.62; 3.31). No association was found between coffee/caffeine consumption and outcomes of fertility treatment (based on two studies). No clear association was found between exposure to coffee/caffeine and natural fertility as measured by fecundability odds ratio (based on three studies) or waiting TTP (based on two studies). CONCLUSION: Results from this meta-analysis support the growing evidence of an association between coffee/caffeine intake and the risk of SAB. However, viewing the reproductive capacity in a broader perspective, there seems to be little, if any, association between coffee/caffeine consumption and fecundity. In general, results from this study are supportive of a precautionary principle advised by health organizations such as European Food Safety Authority (EFSA) and World Health Organization (WHO), although the advised limit of a maximum of two to three cups of coffee/200–300 mg caffeine per day may be too high. Dove Medical Press 2017-12-15 /pmc/articles/PMC5733907/ /pubmed/29276412 http://dx.doi.org/10.2147/CLEP.S146496 Text en © 2017 Lyngsø et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Lyngsø, Julie Ramlau-Hansen, Cecilia Høst Bay, Bjørn Ingerslev, Hans Jakob Hulman, Adam Kesmodel, Ulrik Schiøler Association between coffee or caffeine consumption and fecundity and fertility: a systematic review and dose–response meta-analysis |
title | Association between coffee or caffeine consumption and fecundity and fertility: a systematic review and dose–response meta-analysis |
title_full | Association between coffee or caffeine consumption and fecundity and fertility: a systematic review and dose–response meta-analysis |
title_fullStr | Association between coffee or caffeine consumption and fecundity and fertility: a systematic review and dose–response meta-analysis |
title_full_unstemmed | Association between coffee or caffeine consumption and fecundity and fertility: a systematic review and dose–response meta-analysis |
title_short | Association between coffee or caffeine consumption and fecundity and fertility: a systematic review and dose–response meta-analysis |
title_sort | association between coffee or caffeine consumption and fecundity and fertility: a systematic review and dose–response meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733907/ https://www.ncbi.nlm.nih.gov/pubmed/29276412 http://dx.doi.org/10.2147/CLEP.S146496 |
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