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Modulation of Immune Function in Rats Using Oligosaccharides Extracted from Palm Kernel Cake
To investigate the prebiotic and immunomodulatory effects of PKC extract (OligoPKC) a total of 24 male rats were randomly assigned to three treatment groups receiving basal diet (control), basal diet containing 0.5% OligoPKC, or basal diet containing 1% OligoPKC for four weeks. We found that OligoPK...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733945/ https://www.ncbi.nlm.nih.gov/pubmed/29349067 http://dx.doi.org/10.1155/2017/2576921 |
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author | Faseleh Jahromi, Mohammd Shokryazdan, Parisa Idrus, Zulkifli Ebrahimi, Rohollah Bashokouh, Fatemeh Liang, Juan Boo |
author_facet | Faseleh Jahromi, Mohammd Shokryazdan, Parisa Idrus, Zulkifli Ebrahimi, Rohollah Bashokouh, Fatemeh Liang, Juan Boo |
author_sort | Faseleh Jahromi, Mohammd |
collection | PubMed |
description | To investigate the prebiotic and immunomodulatory effects of PKC extract (OligoPKC) a total of 24 male rats were randomly assigned to three treatment groups receiving basal diet (control), basal diet containing 0.5% OligoPKC, or basal diet containing 1% OligoPKC for four weeks. We found that OligoPKC had no significant effect on the tested growth parameters. However, it increased the size of the total and beneficial bacterial populations while reducing pathogen populations. OligoPKC increased the concentration of immunoglobulins in the serum and cecal contents of rats. It also enhanced the antioxidant capacity of the liver while reducing lipid peroxidation in liver tissue. OligoPKC affected the expression of genes involved in immune system function in the intestine. Therefore, OligoPKC could be considered a potential mannan-based prebiotic for humans and animals due to its beneficial effects on the health and well-being of the model rats. |
format | Online Article Text |
id | pubmed-5733945 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-57339452018-01-18 Modulation of Immune Function in Rats Using Oligosaccharides Extracted from Palm Kernel Cake Faseleh Jahromi, Mohammd Shokryazdan, Parisa Idrus, Zulkifli Ebrahimi, Rohollah Bashokouh, Fatemeh Liang, Juan Boo Biomed Res Int Research Article To investigate the prebiotic and immunomodulatory effects of PKC extract (OligoPKC) a total of 24 male rats were randomly assigned to three treatment groups receiving basal diet (control), basal diet containing 0.5% OligoPKC, or basal diet containing 1% OligoPKC for four weeks. We found that OligoPKC had no significant effect on the tested growth parameters. However, it increased the size of the total and beneficial bacterial populations while reducing pathogen populations. OligoPKC increased the concentration of immunoglobulins in the serum and cecal contents of rats. It also enhanced the antioxidant capacity of the liver while reducing lipid peroxidation in liver tissue. OligoPKC affected the expression of genes involved in immune system function in the intestine. Therefore, OligoPKC could be considered a potential mannan-based prebiotic for humans and animals due to its beneficial effects on the health and well-being of the model rats. Hindawi 2017 2017-11-19 /pmc/articles/PMC5733945/ /pubmed/29349067 http://dx.doi.org/10.1155/2017/2576921 Text en Copyright © 2017 Mohammd Faseleh Jahromi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Faseleh Jahromi, Mohammd Shokryazdan, Parisa Idrus, Zulkifli Ebrahimi, Rohollah Bashokouh, Fatemeh Liang, Juan Boo Modulation of Immune Function in Rats Using Oligosaccharides Extracted from Palm Kernel Cake |
title | Modulation of Immune Function in Rats Using Oligosaccharides Extracted from Palm Kernel Cake |
title_full | Modulation of Immune Function in Rats Using Oligosaccharides Extracted from Palm Kernel Cake |
title_fullStr | Modulation of Immune Function in Rats Using Oligosaccharides Extracted from Palm Kernel Cake |
title_full_unstemmed | Modulation of Immune Function in Rats Using Oligosaccharides Extracted from Palm Kernel Cake |
title_short | Modulation of Immune Function in Rats Using Oligosaccharides Extracted from Palm Kernel Cake |
title_sort | modulation of immune function in rats using oligosaccharides extracted from palm kernel cake |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733945/ https://www.ncbi.nlm.nih.gov/pubmed/29349067 http://dx.doi.org/10.1155/2017/2576921 |
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