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Modulation of Immune Function in Rats Using Oligosaccharides Extracted from Palm Kernel Cake

To investigate the prebiotic and immunomodulatory effects of PKC extract (OligoPKC) a total of 24 male rats were randomly assigned to three treatment groups receiving basal diet (control), basal diet containing 0.5% OligoPKC, or basal diet containing 1% OligoPKC for four weeks. We found that OligoPK...

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Autores principales: Faseleh Jahromi, Mohammd, Shokryazdan, Parisa, Idrus, Zulkifli, Ebrahimi, Rohollah, Bashokouh, Fatemeh, Liang, Juan Boo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733945/
https://www.ncbi.nlm.nih.gov/pubmed/29349067
http://dx.doi.org/10.1155/2017/2576921
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author Faseleh Jahromi, Mohammd
Shokryazdan, Parisa
Idrus, Zulkifli
Ebrahimi, Rohollah
Bashokouh, Fatemeh
Liang, Juan Boo
author_facet Faseleh Jahromi, Mohammd
Shokryazdan, Parisa
Idrus, Zulkifli
Ebrahimi, Rohollah
Bashokouh, Fatemeh
Liang, Juan Boo
author_sort Faseleh Jahromi, Mohammd
collection PubMed
description To investigate the prebiotic and immunomodulatory effects of PKC extract (OligoPKC) a total of 24 male rats were randomly assigned to three treatment groups receiving basal diet (control), basal diet containing 0.5% OligoPKC, or basal diet containing 1% OligoPKC for four weeks. We found that OligoPKC had no significant effect on the tested growth parameters. However, it increased the size of the total and beneficial bacterial populations while reducing pathogen populations. OligoPKC increased the concentration of immunoglobulins in the serum and cecal contents of rats. It also enhanced the antioxidant capacity of the liver while reducing lipid peroxidation in liver tissue. OligoPKC affected the expression of genes involved in immune system function in the intestine. Therefore, OligoPKC could be considered a potential mannan-based prebiotic for humans and animals due to its beneficial effects on the health and well-being of the model rats.
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spelling pubmed-57339452018-01-18 Modulation of Immune Function in Rats Using Oligosaccharides Extracted from Palm Kernel Cake Faseleh Jahromi, Mohammd Shokryazdan, Parisa Idrus, Zulkifli Ebrahimi, Rohollah Bashokouh, Fatemeh Liang, Juan Boo Biomed Res Int Research Article To investigate the prebiotic and immunomodulatory effects of PKC extract (OligoPKC) a total of 24 male rats were randomly assigned to three treatment groups receiving basal diet (control), basal diet containing 0.5% OligoPKC, or basal diet containing 1% OligoPKC for four weeks. We found that OligoPKC had no significant effect on the tested growth parameters. However, it increased the size of the total and beneficial bacterial populations while reducing pathogen populations. OligoPKC increased the concentration of immunoglobulins in the serum and cecal contents of rats. It also enhanced the antioxidant capacity of the liver while reducing lipid peroxidation in liver tissue. OligoPKC affected the expression of genes involved in immune system function in the intestine. Therefore, OligoPKC could be considered a potential mannan-based prebiotic for humans and animals due to its beneficial effects on the health and well-being of the model rats. Hindawi 2017 2017-11-19 /pmc/articles/PMC5733945/ /pubmed/29349067 http://dx.doi.org/10.1155/2017/2576921 Text en Copyright © 2017 Mohammd Faseleh Jahromi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Faseleh Jahromi, Mohammd
Shokryazdan, Parisa
Idrus, Zulkifli
Ebrahimi, Rohollah
Bashokouh, Fatemeh
Liang, Juan Boo
Modulation of Immune Function in Rats Using Oligosaccharides Extracted from Palm Kernel Cake
title Modulation of Immune Function in Rats Using Oligosaccharides Extracted from Palm Kernel Cake
title_full Modulation of Immune Function in Rats Using Oligosaccharides Extracted from Palm Kernel Cake
title_fullStr Modulation of Immune Function in Rats Using Oligosaccharides Extracted from Palm Kernel Cake
title_full_unstemmed Modulation of Immune Function in Rats Using Oligosaccharides Extracted from Palm Kernel Cake
title_short Modulation of Immune Function in Rats Using Oligosaccharides Extracted from Palm Kernel Cake
title_sort modulation of immune function in rats using oligosaccharides extracted from palm kernel cake
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733945/
https://www.ncbi.nlm.nih.gov/pubmed/29349067
http://dx.doi.org/10.1155/2017/2576921
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