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Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence

Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scant. Exposure to cadmium (Cd), a ubiquitous metal associated with well-established toxic and carcinogenic properties, has been hypothesized to one putative cause of PC. Hence, we analyzed recently published observation...

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Autores principales: Buha, Aleksandra, Wallace, David, Matovic, Vesna, Schweitzer, Amie, Oluic, Branislav, Micic, Dusan, Djordjevic, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733953/
https://www.ncbi.nlm.nih.gov/pubmed/29349066
http://dx.doi.org/10.1155/2017/1981837
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author Buha, Aleksandra
Wallace, David
Matovic, Vesna
Schweitzer, Amie
Oluic, Branislav
Micic, Dusan
Djordjevic, Vladimir
author_facet Buha, Aleksandra
Wallace, David
Matovic, Vesna
Schweitzer, Amie
Oluic, Branislav
Micic, Dusan
Djordjevic, Vladimir
author_sort Buha, Aleksandra
collection PubMed
description Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scant. Exposure to cadmium (Cd), a ubiquitous metal associated with well-established toxic and carcinogenic properties, has been hypothesized to one putative cause of PC. Hence, we analyzed recently published observational studies, meta-analyses, and experimental animal and in vitro studies with the aim of summarizing the evidence of Cd involvement in PC development and describing the possible mechanisms. Consolidation of epidemiological data on PC and exposure to Cd indicated a significant association with an elevated risk of PC among general population exposed to Cd. Cadmium exposure of laboratory animals was showed to cause PC supporting the findings suggested by human studies. The concordance with human and animal studies is buttressed by in vitro studies, although in vitro data interpretation is problematic. In most instances, only significant effects are reported, and the concentrations of Cd are excessive, which would skew interpretation. Previous reports suggest that oxidative stress, apoptotic changes, and DNA cross-linking and hypermethylation are involved in Cd-mediated carcinogenesis. Undoubtedly, a significant amount of work is still needed to achieve a better understanding of the Cd involvement in pancreatic cancer which could facilitate prevention, diagnosis, and therapy of this fatal disease.
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spelling pubmed-57339532018-01-18 Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence Buha, Aleksandra Wallace, David Matovic, Vesna Schweitzer, Amie Oluic, Branislav Micic, Dusan Djordjevic, Vladimir Biomed Res Int Review Article Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scant. Exposure to cadmium (Cd), a ubiquitous metal associated with well-established toxic and carcinogenic properties, has been hypothesized to one putative cause of PC. Hence, we analyzed recently published observational studies, meta-analyses, and experimental animal and in vitro studies with the aim of summarizing the evidence of Cd involvement in PC development and describing the possible mechanisms. Consolidation of epidemiological data on PC and exposure to Cd indicated a significant association with an elevated risk of PC among general population exposed to Cd. Cadmium exposure of laboratory animals was showed to cause PC supporting the findings suggested by human studies. The concordance with human and animal studies is buttressed by in vitro studies, although in vitro data interpretation is problematic. In most instances, only significant effects are reported, and the concentrations of Cd are excessive, which would skew interpretation. Previous reports suggest that oxidative stress, apoptotic changes, and DNA cross-linking and hypermethylation are involved in Cd-mediated carcinogenesis. Undoubtedly, a significant amount of work is still needed to achieve a better understanding of the Cd involvement in pancreatic cancer which could facilitate prevention, diagnosis, and therapy of this fatal disease. Hindawi 2017 2017-11-16 /pmc/articles/PMC5733953/ /pubmed/29349066 http://dx.doi.org/10.1155/2017/1981837 Text en Copyright © 2017 Aleksandra Buha et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Buha, Aleksandra
Wallace, David
Matovic, Vesna
Schweitzer, Amie
Oluic, Branislav
Micic, Dusan
Djordjevic, Vladimir
Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence
title Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence
title_full Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence
title_fullStr Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence
title_full_unstemmed Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence
title_short Cadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidence
title_sort cadmium exposure as a putative risk factor for the development of pancreatic cancer: three different lines of evidence
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733953/
https://www.ncbi.nlm.nih.gov/pubmed/29349066
http://dx.doi.org/10.1155/2017/1981837
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