Cargando…
The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features(1)
There is tremendous recent interest in chronic traumatic encephalopathy (CTE) in former collision sport athletes, civilians, and military veterans. This critical review places important recent research results into a historical context. In 2015, preliminary consensus criteria were developed for defi...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734127/ https://www.ncbi.nlm.nih.gov/pubmed/29103039 http://dx.doi.org/10.3233/JAD-170654 |
_version_ | 1783287002401079296 |
---|---|
author | Iverson, Grant L. Keene, C. Dirk Perry, George Castellani, Rudolph J. |
author_facet | Iverson, Grant L. Keene, C. Dirk Perry, George Castellani, Rudolph J. |
author_sort | Iverson, Grant L. |
collection | PubMed |
description | There is tremendous recent interest in chronic traumatic encephalopathy (CTE) in former collision sport athletes, civilians, and military veterans. This critical review places important recent research results into a historical context. In 2015, preliminary consensus criteria were developed for defining the neuropathology of CTE, which substantially narrowed the pathology previously reported to be characteristic. There are no agreed upon clinical criteria for diagnosis, although sets of criteria have been proposed for research purposes. A prevailing theory is that CTE is an inexorably progressive neurodegenerative disease within the molecular classification of the tauopathies. However, historical and recent evidence suggests that CTE, as it is presented in the literature, might not be pathologically or clinically progressive in a substantial percentage of people. At present, it is not known whether the emergence, course, or severity of clinical symptoms can be predicted by specific combinations of neuropathologies, thresholds for accumulation of pathology, or regional distributions of pathologies. More research is needed to determine the extent to which the neuropathology ascribed to long-term effects of neurotrauma is static, progressive, or both. Disambiguating the pathology from the broad array of clinical features that have been reported in recent studies might facilitate and accelerate research— and improve understanding of CTE. |
format | Online Article Text |
id | pubmed-5734127 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-57341272017-12-20 The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features(1) Iverson, Grant L. Keene, C. Dirk Perry, George Castellani, Rudolph J. J Alzheimers Dis Review There is tremendous recent interest in chronic traumatic encephalopathy (CTE) in former collision sport athletes, civilians, and military veterans. This critical review places important recent research results into a historical context. In 2015, preliminary consensus criteria were developed for defining the neuropathology of CTE, which substantially narrowed the pathology previously reported to be characteristic. There are no agreed upon clinical criteria for diagnosis, although sets of criteria have been proposed for research purposes. A prevailing theory is that CTE is an inexorably progressive neurodegenerative disease within the molecular classification of the tauopathies. However, historical and recent evidence suggests that CTE, as it is presented in the literature, might not be pathologically or clinically progressive in a substantial percentage of people. At present, it is not known whether the emergence, course, or severity of clinical symptoms can be predicted by specific combinations of neuropathologies, thresholds for accumulation of pathology, or regional distributions of pathologies. More research is needed to determine the extent to which the neuropathology ascribed to long-term effects of neurotrauma is static, progressive, or both. Disambiguating the pathology from the broad array of clinical features that have been reported in recent studies might facilitate and accelerate research— and improve understanding of CTE. IOS Press 2017-11-28 /pmc/articles/PMC5734127/ /pubmed/29103039 http://dx.doi.org/10.3233/JAD-170654 Text en © 2018 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Iverson, Grant L. Keene, C. Dirk Perry, George Castellani, Rudolph J. The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features(1) |
title | The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features(1) |
title_full | The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features(1) |
title_fullStr | The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features(1) |
title_full_unstemmed | The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features(1) |
title_short | The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features(1) |
title_sort | need to separate chronic traumatic encephalopathy neuropathology from clinical features(1) |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734127/ https://www.ncbi.nlm.nih.gov/pubmed/29103039 http://dx.doi.org/10.3233/JAD-170654 |
work_keys_str_mv | AT iversongrantl theneedtoseparatechronictraumaticencephalopathyneuropathologyfromclinicalfeatures1 AT keenecdirk theneedtoseparatechronictraumaticencephalopathyneuropathologyfromclinicalfeatures1 AT perrygeorge theneedtoseparatechronictraumaticencephalopathyneuropathologyfromclinicalfeatures1 AT castellanirudolphj theneedtoseparatechronictraumaticencephalopathyneuropathologyfromclinicalfeatures1 AT iversongrantl needtoseparatechronictraumaticencephalopathyneuropathologyfromclinicalfeatures1 AT keenecdirk needtoseparatechronictraumaticencephalopathyneuropathologyfromclinicalfeatures1 AT perrygeorge needtoseparatechronictraumaticencephalopathyneuropathologyfromclinicalfeatures1 AT castellanirudolphj needtoseparatechronictraumaticencephalopathyneuropathologyfromclinicalfeatures1 |