Two novel Mg(II)-based and Zn(II)-based complexes: inhibiting growth of human liver cancer cells

Two new Mg(II)-based and Zn(II)-based coordination polymers, {[Mg(3)(BTB)(DMA)(4)](DMA)(2)}(n) (1, H(3)BTB=1,3,5-benzenetrisbenzoic acid, DMA=N,N-dimethylacetamide) and {(H(2)NMe(2))(2)[Zn(3)(BTB)(2)(OH)(Im)](DMF)(9)(MeOH)(7)}(n) (2, Im=imidazole, DMF=N,N-dimethylformamide), have been successfully s...

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Detalles Bibliográficos
Autores principales: Liu, N., Ding, D., Wang, L., Zhao, H., Zhu, L., Geng, X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734187/
https://www.ncbi.nlm.nih.gov/pubmed/29267507
http://dx.doi.org/10.1590/1414-431X20176929
Descripción
Sumario:Two new Mg(II)-based and Zn(II)-based coordination polymers, {[Mg(3)(BTB)(DMA)(4)](DMA)(2)}(n) (1, H(3)BTB=1,3,5-benzenetrisbenzoic acid, DMA=N,N-dimethylacetamide) and {(H(2)NMe(2))(2)[Zn(3)(BTB)(2)(OH)(Im)](DMF)(9)(MeOH)(7)}(n) (2, Im=imidazole, DMF=N,N-dimethylformamide), have been successfully synthesized and structurally characterized under solvothermal conditions. 1 contains a linear [Mg(3)(COO)(6)] cluster that connected by the fully deprotonated BTB(3-) ligands to give a kgd-type 2D bilayer structure; 2 represents a microporous 3D pillar-layered system based on the binuclear Zn units and pillared Im ligands, which shows a (3,5)-connected hms topological net. In addition, in vitro anticancer activities of compounds 1 and 2 on 4 human liver cancer cells (HB611, HHCC, BEL-7405 and SMMC-7721) were determined.

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