Cargando…

Investigating the safety and activity of the use of BTT1023 (Timolumab), in the treatment of patients with primary sclerosing cholangitis (BUTEO): A single-arm, two-stage, open-label, multi-centre, phase II clinical trial protocol

INTRODUCTION: Primary sclerosing cholangitis (PSC) is a progressive inflammatory liver disease characterised by relentless liver fibrosis and a high unmet need for new therapies. Preventing fibrosis represents an important area of interest in the development of vital new drugs. Vascular adhesion pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arndtz, Katherine, Corrigan, Margaret, Rowe, Anna, Kirkham, Amanda, Barton, Darren, Fox, Richard P, Llewellyn, Laura, Athwal, Amrita, Wilkhu, Manpreet, Chen, Yung-Yi, Weston, Chris, Desai, Amisha, Adams, David H, Hirschfield, Gideon M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2017
Materias:	Gastroenterology and Hepatology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734279/ https://www.ncbi.nlm.nih.gov/pubmed/28674140 http://dx.doi.org/10.1136/bmjopen-2016-015081

Ejemplares similares

Rare but heard: using asynchronous virtual focus groups, interviews and roundtable discussions to create a personalised psychological intervention for primary sclerosing cholangitis: a protocol
por: Ranieri, Veronica, et al.
Publicado: (2019)

Barriers to implementation of stratified care in primary biliary cholangitis: a scoping exercise
por: Corrigan, Margaret, et al.
Publicado: (2019)

Intrahepatic macrophage populations in the pathophysiology of primary sclerosing cholangitis
por: Chen, Yung-Yi, et al.
Publicado: (2019)

Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner
por: Trivedi, Palak J, et al.
Publicado: (2018)

A novel prognostic model for transplant-free survival in primary sclerosing cholangitis
por: de Vries, Elisabeth M, et al.
Publicado: (2018)

An Unusual Presentation of Crohn’s Disease and Primary Sclerosing Cholangitis
por: Ekanayake, Lakmal S, et al.
Publicado: (2022)

Risk factors for post-endoscopic retrograde cholangiopancreatography cholangitis in patients with hepatic alveolar echinococcosis—an observational study
por: Du, Fei, et al.
Publicado: (2022)

A Case of Secondary Sclerosing Cholangitis in the setting of Non-Hodgkin’s Lymphoma
por: Shaikh, Hira, et al.
Publicado: (2019)

Does neutrophil-to-lymphocyte ratio predict 1-year mortality in patients with primary biliary cholangitis? Results from a retrospective study with validation cohort
por: Lin, Lin, et al.
Publicado: (2017)

Factors associated with severity and persistence of fatigue in patients with primary biliary cholangitis: study protocol of a prospective cohort study with a mixed-methods approach (SOMA.LIV)
por: Toussaint, Anne, et al.
Publicado: (2022)

Risk of Hepatobiliary-Gastrointestinal Malignancies and Appropriate Cancer Surveillance in Patients With Primary Sclerosing Cholangitis
por: Yadlapati, Sujani, et al.
Publicado: (2021)

Previously Untreated Ulcerative Colitis With Newly Diagnosed Primary Sclerosing Cholangitis: A Case Report
por: Tekeste, Rahel, et al.
Publicado: (2023)

Number needed to treat with ursodeoxycholic acid therapy to prevent liver transplantation or death in primary biliary cholangitis
por: Harms, Maren H, et al.
Publicado: (2020)

Infection due to Buteo buteo herpesvirus in a common buzzard (Buteo buteo insularum)
por: Suárez-Santana, Cristian M., et al.
Publicado: (2023)

The NOTA study: non-operative treatment for acute appendicitis: prospective study on the efficacy and safety of antibiotic treatment (amoxicillin and clavulanic acid) in patients with right sided lower abdominal pain
por: Tugnoli, Gregorio, et al.
Publicado: (2011)

The European lactase persistence genotype determines the lactase persistence state and correlates with gastrointestinal symptoms in the Hispanic and Amerindian Chilean population: a case–control and population-based study
por: Morales, Eugenia, et al.
Publicado: (2011)

Viusid, a nutritional supplement, increases survival and reduces disease progression in HCV-related decompensated cirrhosis: a randomised and controlled trial
por: Vilar Gomez, Eduardo, et al.
Publicado: (2011)

Fall in peptic ulcer mortality associated with increased consultant input, prompt surgery and use of high dependency care identified through peer-review audit
por: Aga, Hiba, et al.
Publicado: (2012)

Thirty-day mortality after elective and emergency total colectomy in Danish patients with inflammatory bowel disease: a population-based nationwide cohort study
por: Tøttrup, Anders, et al.
Publicado: (2012)

Characteristics of randomised trials on diseases in the digestive system registered in ClinicalTrials.gov: a retrospective analysis
por: Wildt, Signe, et al.
Publicado: (2011)

Retrospective study of patients with acute pancreatitis: is serum amylase still required?
por: Gomez, Dhanwant, et al.
Publicado: (2012)

Barriers and facilitators to change in the organisation and delivery of endoscopy services in England and Wales: a focus group study
por: Rapport, Frances, et al.
Publicado: (2012)

Life-event stress induced by the Great East Japan Earthquake was associated with relapse in ulcerative colitis but not Crohn's disease: a retrospective cohort study
por: Shiga, Hisashi, et al.
Publicado: (2013)

Liraglutide efficacy and action in non-alcoholic steatohepatitis (LEAN): study protocol for a phase II multicentre, double-blinded, randomised, controlled trial
por: Armstrong, Matthew J, et al.
Publicado: (2013)

Corticosteroids and risk of gastrointestinal bleeding: a systematic review and meta-analysis
por: Narum, Sigrid, et al.
Publicado: (2014)

Factors associated with failure of enhanced recovery protocol in patients undergoing major hepatobiliary and pancreatic surgery: a retrospective cohort study
por: Lee, Anna, et al.
Publicado: (2014)

Pair-wise comparison analysis of differential expression of mRNAs in early and advanced stage primary colorectal adenocarcinomas
por: Lau, Tze Pheng, et al.
Publicado: (2014)

Comparison and validation of International Consensus Diagnostic Criteria for diagnosis of autoimmune pancreatitis from pancreatic cancer in a Taiwanese cohort
por: Chang, Ming-Chu, et al.
Publicado: (2014)

A mixed methods feasibility study to evaluate the use of a low-intensity, nurse-delivered cognitive behavioural therapy for the treatment of irritable bowel syndrome
por: Dainty, Andrew David, et al.
Publicado: (2014)

Unexplained abdominal pain as a driver for inappropriate therapeutics: an audit on the use of intravenous proton pump inhibitors
por: Lai, Pauline Siew Mei, et al.
Publicado: (2014)

Conservative treatment of adhesive small bowel obstruction in children: a systematic review
por: Lin, Lung-Huang, et al.
Publicado: (2014)

Differences in healthcare expenditures for inflammatory bowel disease by insurance status, income, and clinical care setting
por: Park, Michelle D., et al.
Publicado: (2014)

Ethnic variations in five lower gastrointestinal diseases: Scottish Health and Ethnicity Linkage Study
por: Bhopal, Raj S, et al.
Publicado: (2014)

Comparison of imputation methods for missing laboratory data in medicine
por: Waljee, Akbar K, et al.
Publicado: (2013)

Antiviral therapy for prevention of hepatocellular carcinoma and mortality in chronic hepatitis B: systematic review and meta-analysis
por: Thiele, Maja, et al.
Publicado: (2013)

Comprehensive screening for PRSS1, SPINK1, CFTR, CTRC and CLDN2 gene mutations in Chinese paediatric patients with idiopathic chronic pancreatitis: a cohort study
por: Wang, Wei, et al.
Publicado: (2013)

Outcomes of transplantation of livers from donation after circulatory death donors in the UK: a cohort study
por: Callaghan, Christopher J, et al.
Publicado: (2013)

Trial-based cost-effectiveness analysis comparing surgical and endoscopic drainage in patients with obstructive chronic pancreatitis
por: Laramée, Philippe, et al.
Publicado: (2013)

Education level and survival after oesophageal cancer surgery: a prospective population-based cohort study
por: Brusselaers, Nele, et al.
Publicado: (2013)

Hepatotoxicity of isotretinoin in patients with acne and Gilbert's syndrome: a comparative study
por: Fernández-Crehuet, Pablo, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_c6r1fioo6irfeka5fdfvmmbm45