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Seroprevalence of hepatitis B virus infection in Cameroon: a systematic review and meta-analysis
OBJECTIVE: Better knowledge of hepatitis B virus (HBV) infection prevalence at the national level can help to implement pertinent strategies to address HBV related burden. The aim was to estimate the seroprevalence of HBV infection in Cameroon. DESIGN: Systematic review and meta-analysis. PARTICIPAN...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734365/ https://www.ncbi.nlm.nih.gov/pubmed/28667212 http://dx.doi.org/10.1136/bmjopen-2016-015298 |
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author | Bigna, Jean Joel Amougou, Marie A Asangbeh, Serra Lem Kenne, Angeladine Malaha Noumegni, Steve Raoul N Ngo-Malabo, Elodie T Noubiap, Jean Jacques |
author_facet | Bigna, Jean Joel Amougou, Marie A Asangbeh, Serra Lem Kenne, Angeladine Malaha Noumegni, Steve Raoul N Ngo-Malabo, Elodie T Noubiap, Jean Jacques |
author_sort | Bigna, Jean Joel |
collection | PubMed |
description | OBJECTIVE: Better knowledge of hepatitis B virus (HBV) infection prevalence at the national level can help to implement pertinent strategies to address HBV related burden. The aim was to estimate the seroprevalence of HBV infection in Cameroon. DESIGN: Systematic review and meta-analysis. PARTICIPANTS: People residing in Cameroon. DATA SOURCES: Electronic databases including PubMed/MEDLINE, African Journals Online (AJOL), ScienceDirect, WHO-Afro Library, WHO-IRIS, African Index Medicus, National Institute of Statistics and National AIDS Control Committee, Cameroon; regardless of language and from 1 January 2000 to 30 September 2016. This was completed with a manual search of references of relevant papers. Risk of bias in methodology of studies was measured using the Newcastle-Ottawa Scale. RESULTS: Out of 511 retrieved papers, 44 studies with a total of 105 603 individuals were finally included. The overall pooled seroprevalence was 11.2% (95% CI 9.7% to 12.8%) with high heterogeneity between studies (I (2)=97.9%). Egger’s test showed no publication bias (p=0.167). A sensitivity analysis excluding individuals at high risk of HBV infection and after adjustment using trim and fill method showed a pooled seroprevalence of 10.6% (95% CI 8.6% to 12.6%) among 100 501 individuals (general population, blood donors and pregnant women). Sources of heterogeneity included geographical regions across country and setting (rural 13.3% vs urban 9.0%), and implementation of HBV universal immunisation (born after 9.2% vs born before 0.7%). Sex, site, timing of data collection, HBV screening tools and methodological quality of studies were not sources of heterogeneity. LIMITATION: Only a third of the studies had low risk of bias in their methodology. CONCLUSION: The seroprevalence of HBV infection in Cameroon is high. Effective strategies to interrupt the transmission of HBV are urgently required. Specific attention is needed for rural settings, certain regions and people born before the implementation of the HBV universal immunisation programme in Cameroon in 2005. REGISTRATION: PROSPERO, CRD42016042654. |
format | Online Article Text |
id | pubmed-5734365 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-57343652017-12-20 Seroprevalence of hepatitis B virus infection in Cameroon: a systematic review and meta-analysis Bigna, Jean Joel Amougou, Marie A Asangbeh, Serra Lem Kenne, Angeladine Malaha Noumegni, Steve Raoul N Ngo-Malabo, Elodie T Noubiap, Jean Jacques BMJ Open Infectious Diseases OBJECTIVE: Better knowledge of hepatitis B virus (HBV) infection prevalence at the national level can help to implement pertinent strategies to address HBV related burden. The aim was to estimate the seroprevalence of HBV infection in Cameroon. DESIGN: Systematic review and meta-analysis. PARTICIPANTS: People residing in Cameroon. DATA SOURCES: Electronic databases including PubMed/MEDLINE, African Journals Online (AJOL), ScienceDirect, WHO-Afro Library, WHO-IRIS, African Index Medicus, National Institute of Statistics and National AIDS Control Committee, Cameroon; regardless of language and from 1 January 2000 to 30 September 2016. This was completed with a manual search of references of relevant papers. Risk of bias in methodology of studies was measured using the Newcastle-Ottawa Scale. RESULTS: Out of 511 retrieved papers, 44 studies with a total of 105 603 individuals were finally included. The overall pooled seroprevalence was 11.2% (95% CI 9.7% to 12.8%) with high heterogeneity between studies (I (2)=97.9%). Egger’s test showed no publication bias (p=0.167). A sensitivity analysis excluding individuals at high risk of HBV infection and after adjustment using trim and fill method showed a pooled seroprevalence of 10.6% (95% CI 8.6% to 12.6%) among 100 501 individuals (general population, blood donors and pregnant women). Sources of heterogeneity included geographical regions across country and setting (rural 13.3% vs urban 9.0%), and implementation of HBV universal immunisation (born after 9.2% vs born before 0.7%). Sex, site, timing of data collection, HBV screening tools and methodological quality of studies were not sources of heterogeneity. LIMITATION: Only a third of the studies had low risk of bias in their methodology. CONCLUSION: The seroprevalence of HBV infection in Cameroon is high. Effective strategies to interrupt the transmission of HBV are urgently required. Specific attention is needed for rural settings, certain regions and people born before the implementation of the HBV universal immunisation programme in Cameroon in 2005. REGISTRATION: PROSPERO, CRD42016042654. BMJ Publishing Group 2017-06-30 /pmc/articles/PMC5734365/ /pubmed/28667212 http://dx.doi.org/10.1136/bmjopen-2016-015298 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Infectious Diseases Bigna, Jean Joel Amougou, Marie A Asangbeh, Serra Lem Kenne, Angeladine Malaha Noumegni, Steve Raoul N Ngo-Malabo, Elodie T Noubiap, Jean Jacques Seroprevalence of hepatitis B virus infection in Cameroon: a systematic review and meta-analysis |
title | Seroprevalence of hepatitis B virus infection in Cameroon: a systematic review and meta-analysis |
title_full | Seroprevalence of hepatitis B virus infection in Cameroon: a systematic review and meta-analysis |
title_fullStr | Seroprevalence of hepatitis B virus infection in Cameroon: a systematic review and meta-analysis |
title_full_unstemmed | Seroprevalence of hepatitis B virus infection in Cameroon: a systematic review and meta-analysis |
title_short | Seroprevalence of hepatitis B virus infection in Cameroon: a systematic review and meta-analysis |
title_sort | seroprevalence of hepatitis b virus infection in cameroon: a systematic review and meta-analysis |
topic | Infectious Diseases |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734365/ https://www.ncbi.nlm.nih.gov/pubmed/28667212 http://dx.doi.org/10.1136/bmjopen-2016-015298 |
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