Cargando…

DichroMatch at the protein circular dichroism data bank (DM@PCDDB): A web‐based tool for identifying protein nearest neighbors using circular dichroism spectroscopy

Circular dichroism spectroscopy is a well‐used, but simple method in structural biology for providing information on the secondary structure and folds of proteins. DichroMatch (DM@PCDDB) is an online tool that is newly available in the Protein Circular Dichroism Data Bank (PCDDB), which takes advant...

Descripción completa

Detalles Bibliográficos
Autores principales: Whitmore, Lee, Mavridis, Lazaros, Wallace, B.A., Janes, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734389/
https://www.ncbi.nlm.nih.gov/pubmed/28580679
http://dx.doi.org/10.1002/pro.3207
Descripción
Sumario:Circular dichroism spectroscopy is a well‐used, but simple method in structural biology for providing information on the secondary structure and folds of proteins. DichroMatch (DM@PCDDB) is an online tool that is newly available in the Protein Circular Dichroism Data Bank (PCDDB), which takes advantage of the wealth of spectral and metadata deposited therein, to enable identification of spectral nearest neighbors of a query protein based on four different methods of spectral matching. DM@PCDDB can potentially provide novel information about structural relationships between proteins and can be used in comparison studies of protein homologs and orthologs.