Cargando…
A favorable cardiometabolic profile is associated with the G allele of the genetic variant rs5068 in African Americans: The Multi-Ethnic Study of Atherosclerosis (MESA)
In whites, the minor G allele of the atrial natriuretic peptide (ANP) genetic variant rs5068 is associated with higher circulating levels of ANP and B-type natriuretic peptide (BNP), lower risk of hypertension, higher high-density lipoprotein (HDL) cholesterol plasma levels, and lower prevalence of...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734753/ https://www.ncbi.nlm.nih.gov/pubmed/29253899 http://dx.doi.org/10.1371/journal.pone.0189858 |
_version_ | 1783287099077689344 |
---|---|
author | Cannone, Valentina Scott, Christopher G. Decker, Paul A. Larson, Nicholas B. Palmas, Walter Taylor, Kent D. Wang, Thomas J. Gupta, Deepak K. Bielinski, Suzette J. Burnett, John C. |
author_facet | Cannone, Valentina Scott, Christopher G. Decker, Paul A. Larson, Nicholas B. Palmas, Walter Taylor, Kent D. Wang, Thomas J. Gupta, Deepak K. Bielinski, Suzette J. Burnett, John C. |
author_sort | Cannone, Valentina |
collection | PubMed |
description | In whites, the minor G allele of the atrial natriuretic peptide (ANP) genetic variant rs5068 is associated with higher circulating levels of ANP and B-type natriuretic peptide (BNP), lower risk of hypertension, higher high-density lipoprotein (HDL) cholesterol plasma levels, and lower prevalence of obesity and metabolic syndrome. The observed phenotype is consistent with the blood pressure lowering and metabolic properties of ANP and BNP. The cardiovascular and metabolic phenotype associated with rs5068 genotypes in African Americans is undefined. We genotyped 1631 African Americans in the Multi-Ethnic Study of Atherosclerosis (MESA) for rs5068 and investigated their phenotype. Genotype frequencies of rs5068 were 93.2% AA (n = 1520), 6.7% AG (n = 110) and 0.1% GG (n = 1). All subsequent analyses are AG + GG versus AA genotype. Using a Bonferroni corrected level of significance of 0.005, the prevalence of metabolic syndrome (23% vs 38%, age-sex-adjusted p = 0.002) and triglycerides plasma values (76 vs 90 mg/dl, age-sex-BMI adjusted p = 0.004) were both significantly lower in the AG+GG genotypes. In the AG+GG genotypes, the prevalence of diabetes (8% vs 18%, age-sex-BMI-adjusted p = 0.02) and insulin plasma levels tended to be lower (4.8 vs 5.7 μU/ml, age-sex-BMI adjusted p = 0.04) whereas HDL-cholesterol levels tended to be higher (55 vs 50 mg/dl, age-sex-BMI-adjusted p = 0.04). No association was found with hypertension. The association between the rs5068 G allele and a favorable metabolic phenotype is now shown in African Americans. The rs5068 AG+GG genotypes are associated with lower prevalence of metabolic syndrome and lower triglycerides values. |
format | Online Article Text |
id | pubmed-5734753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-57347532017-12-22 A favorable cardiometabolic profile is associated with the G allele of the genetic variant rs5068 in African Americans: The Multi-Ethnic Study of Atherosclerosis (MESA) Cannone, Valentina Scott, Christopher G. Decker, Paul A. Larson, Nicholas B. Palmas, Walter Taylor, Kent D. Wang, Thomas J. Gupta, Deepak K. Bielinski, Suzette J. Burnett, John C. PLoS One Research Article In whites, the minor G allele of the atrial natriuretic peptide (ANP) genetic variant rs5068 is associated with higher circulating levels of ANP and B-type natriuretic peptide (BNP), lower risk of hypertension, higher high-density lipoprotein (HDL) cholesterol plasma levels, and lower prevalence of obesity and metabolic syndrome. The observed phenotype is consistent with the blood pressure lowering and metabolic properties of ANP and BNP. The cardiovascular and metabolic phenotype associated with rs5068 genotypes in African Americans is undefined. We genotyped 1631 African Americans in the Multi-Ethnic Study of Atherosclerosis (MESA) for rs5068 and investigated their phenotype. Genotype frequencies of rs5068 were 93.2% AA (n = 1520), 6.7% AG (n = 110) and 0.1% GG (n = 1). All subsequent analyses are AG + GG versus AA genotype. Using a Bonferroni corrected level of significance of 0.005, the prevalence of metabolic syndrome (23% vs 38%, age-sex-adjusted p = 0.002) and triglycerides plasma values (76 vs 90 mg/dl, age-sex-BMI adjusted p = 0.004) were both significantly lower in the AG+GG genotypes. In the AG+GG genotypes, the prevalence of diabetes (8% vs 18%, age-sex-BMI-adjusted p = 0.02) and insulin plasma levels tended to be lower (4.8 vs 5.7 μU/ml, age-sex-BMI adjusted p = 0.04) whereas HDL-cholesterol levels tended to be higher (55 vs 50 mg/dl, age-sex-BMI-adjusted p = 0.04). No association was found with hypertension. The association between the rs5068 G allele and a favorable metabolic phenotype is now shown in African Americans. The rs5068 AG+GG genotypes are associated with lower prevalence of metabolic syndrome and lower triglycerides values. Public Library of Science 2017-12-18 /pmc/articles/PMC5734753/ /pubmed/29253899 http://dx.doi.org/10.1371/journal.pone.0189858 Text en © 2017 Cannone et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Cannone, Valentina Scott, Christopher G. Decker, Paul A. Larson, Nicholas B. Palmas, Walter Taylor, Kent D. Wang, Thomas J. Gupta, Deepak K. Bielinski, Suzette J. Burnett, John C. A favorable cardiometabolic profile is associated with the G allele of the genetic variant rs5068 in African Americans: The Multi-Ethnic Study of Atherosclerosis (MESA) |
title | A favorable cardiometabolic profile is associated with the G allele of the genetic variant rs5068 in African Americans: The Multi-Ethnic Study of Atherosclerosis (MESA) |
title_full | A favorable cardiometabolic profile is associated with the G allele of the genetic variant rs5068 in African Americans: The Multi-Ethnic Study of Atherosclerosis (MESA) |
title_fullStr | A favorable cardiometabolic profile is associated with the G allele of the genetic variant rs5068 in African Americans: The Multi-Ethnic Study of Atherosclerosis (MESA) |
title_full_unstemmed | A favorable cardiometabolic profile is associated with the G allele of the genetic variant rs5068 in African Americans: The Multi-Ethnic Study of Atherosclerosis (MESA) |
title_short | A favorable cardiometabolic profile is associated with the G allele of the genetic variant rs5068 in African Americans: The Multi-Ethnic Study of Atherosclerosis (MESA) |
title_sort | favorable cardiometabolic profile is associated with the g allele of the genetic variant rs5068 in african americans: the multi-ethnic study of atherosclerosis (mesa) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734753/ https://www.ncbi.nlm.nih.gov/pubmed/29253899 http://dx.doi.org/10.1371/journal.pone.0189858 |
work_keys_str_mv | AT cannonevalentina afavorablecardiometabolicprofileisassociatedwiththegalleleofthegeneticvariantrs5068inafricanamericansthemultiethnicstudyofatherosclerosismesa AT scottchristopherg afavorablecardiometabolicprofileisassociatedwiththegalleleofthegeneticvariantrs5068inafricanamericansthemultiethnicstudyofatherosclerosismesa AT deckerpaula afavorablecardiometabolicprofileisassociatedwiththegalleleofthegeneticvariantrs5068inafricanamericansthemultiethnicstudyofatherosclerosismesa AT larsonnicholasb afavorablecardiometabolicprofileisassociatedwiththegalleleofthegeneticvariantrs5068inafricanamericansthemultiethnicstudyofatherosclerosismesa AT palmaswalter afavorablecardiometabolicprofileisassociatedwiththegalleleofthegeneticvariantrs5068inafricanamericansthemultiethnicstudyofatherosclerosismesa AT taylorkentd afavorablecardiometabolicprofileisassociatedwiththegalleleofthegeneticvariantrs5068inafricanamericansthemultiethnicstudyofatherosclerosismesa AT wangthomasj afavorablecardiometabolicprofileisassociatedwiththegalleleofthegeneticvariantrs5068inafricanamericansthemultiethnicstudyofatherosclerosismesa AT guptadeepakk afavorablecardiometabolicprofileisassociatedwiththegalleleofthegeneticvariantrs5068inafricanamericansthemultiethnicstudyofatherosclerosismesa AT bielinskisuzettej afavorablecardiometabolicprofileisassociatedwiththegalleleofthegeneticvariantrs5068inafricanamericansthemultiethnicstudyofatherosclerosismesa AT burnettjohnc afavorablecardiometabolicprofileisassociatedwiththegalleleofthegeneticvariantrs5068inafricanamericansthemultiethnicstudyofatherosclerosismesa AT cannonevalentina favorablecardiometabolicprofileisassociatedwiththegalleleofthegeneticvariantrs5068inafricanamericansthemultiethnicstudyofatherosclerosismesa AT scottchristopherg favorablecardiometabolicprofileisassociatedwiththegalleleofthegeneticvariantrs5068inafricanamericansthemultiethnicstudyofatherosclerosismesa AT deckerpaula favorablecardiometabolicprofileisassociatedwiththegalleleofthegeneticvariantrs5068inafricanamericansthemultiethnicstudyofatherosclerosismesa AT larsonnicholasb favorablecardiometabolicprofileisassociatedwiththegalleleofthegeneticvariantrs5068inafricanamericansthemultiethnicstudyofatherosclerosismesa AT palmaswalter favorablecardiometabolicprofileisassociatedwiththegalleleofthegeneticvariantrs5068inafricanamericansthemultiethnicstudyofatherosclerosismesa AT taylorkentd favorablecardiometabolicprofileisassociatedwiththegalleleofthegeneticvariantrs5068inafricanamericansthemultiethnicstudyofatherosclerosismesa AT wangthomasj favorablecardiometabolicprofileisassociatedwiththegalleleofthegeneticvariantrs5068inafricanamericansthemultiethnicstudyofatherosclerosismesa AT guptadeepakk favorablecardiometabolicprofileisassociatedwiththegalleleofthegeneticvariantrs5068inafricanamericansthemultiethnicstudyofatherosclerosismesa AT bielinskisuzettej favorablecardiometabolicprofileisassociatedwiththegalleleofthegeneticvariantrs5068inafricanamericansthemultiethnicstudyofatherosclerosismesa AT burnettjohnc favorablecardiometabolicprofileisassociatedwiththegalleleofthegeneticvariantrs5068inafricanamericansthemultiethnicstudyofatherosclerosismesa |