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Inhibiting DPP4 in a mouse model of HHT1 results in a shift towards regenerative macrophages and reduces fibrosis after myocardial infarction

AIMS: Hereditary Hemorrhagic Telangiectasia type-1 (HHT1) is a genetic vascular disorder caused by haploinsufficiency of the TGFβ co-receptor endoglin. Dysfunctional homing of HHT1 mononuclear cells (MNCs) towards the infarcted myocardium hampers cardiac recovery. HHT1-MNCs have elevated expression...

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Detalles Bibliográficos
Autores principales:	Dingenouts, Calinda K. E., Bakker, Wineke, Lodder, Kirsten, Wiesmeijer, Karien C., Moerkamp, Asja T., Maring, Janita A., Arthur, Helen M., Smits, Anke M., Goumans, Marie-José
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734765/ https://www.ncbi.nlm.nih.gov/pubmed/29253907 http://dx.doi.org/10.1371/journal.pone.0189805

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