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Determinants for adherence to continuous positive airway pressure therapy in obstructive sleep apnea

BACKGROUND: Continuous positive airway pressure (CPAP) therapy is an efficacious treatment for patients diagnosed with obstructive sleep apnea (OSA). However, there are only few data on long-term adherence. The aim of this study is to quantify the extent of non-adherence and describe the clinical ch...

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Autores principales: Jacobsen, Anne Roed, Eriksen, Freja, Hansen, Rasmus Würgler, Erlandsen, Mogens, Thorup, Line, Damgård, Mette Bjerre, Kirkegaard, Martin Glümer, Hansen, Klavs Würgler
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734784/
https://www.ncbi.nlm.nih.gov/pubmed/29253872
http://dx.doi.org/10.1371/journal.pone.0189614
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author Jacobsen, Anne Roed
Eriksen, Freja
Hansen, Rasmus Würgler
Erlandsen, Mogens
Thorup, Line
Damgård, Mette Bjerre
Kirkegaard, Martin Glümer
Hansen, Klavs Würgler
author_facet Jacobsen, Anne Roed
Eriksen, Freja
Hansen, Rasmus Würgler
Erlandsen, Mogens
Thorup, Line
Damgård, Mette Bjerre
Kirkegaard, Martin Glümer
Hansen, Klavs Würgler
author_sort Jacobsen, Anne Roed
collection PubMed
description BACKGROUND: Continuous positive airway pressure (CPAP) therapy is an efficacious treatment for patients diagnosed with obstructive sleep apnea (OSA). However, there are only few data on long-term adherence. The aim of this study is to quantify the extent of non-adherence and describe the clinical characteristics. METHODS: A retrospective study including 695 patients with newly diagnosed OSA and prescribed CPAP therapy within an inclusion period of 14 months. All patients were offered free of charge individually adjusted CPAP therapy. Data on comorbidity, medication, BMI and Epworth Sleepiness Score (ESS) were obtained by questionnaires and consultation with an otorhinolaryngeal specialist. RESULTS: The median follow-up time after initiating CPAP therapy was 3.0 (range 2.4–3.6) years. An adherence rate of 89% was found for severe OSA, 71% for moderate OSA and 55% for mild OSA. 18% initiated humidification. Patients adherent to CPAP had a significantly higher Body Mass Index (BMI), Apnea Hypopnea Index (AHI), Oxygen Desaturation Index (ODI) and ESS compared to non-adherent patients. Furthermore, adherence was associated with a higher frequency of observed interrupted breathing, a less frequent use of hypnotic drugs, fewer smokers, and they were more often offered humidification. Age, gender and comorbidity were not significantly associated with adherence. In a Cox model only AHI (Hazard Ratio (HR) 0.963, p < 0.001), ESS (HR 0.939, p = 0.001) and smoking (HR 1.576, p = 0.022) were independently associated with CPAP non-adherence. CONCLUSIONS: The severity of OSA, subjective daytime sleepiness and smoking status are independently related to adherence to CPAP therapy.
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spelling pubmed-57347842017-12-22 Determinants for adherence to continuous positive airway pressure therapy in obstructive sleep apnea Jacobsen, Anne Roed Eriksen, Freja Hansen, Rasmus Würgler Erlandsen, Mogens Thorup, Line Damgård, Mette Bjerre Kirkegaard, Martin Glümer Hansen, Klavs Würgler PLoS One Research Article BACKGROUND: Continuous positive airway pressure (CPAP) therapy is an efficacious treatment for patients diagnosed with obstructive sleep apnea (OSA). However, there are only few data on long-term adherence. The aim of this study is to quantify the extent of non-adherence and describe the clinical characteristics. METHODS: A retrospective study including 695 patients with newly diagnosed OSA and prescribed CPAP therapy within an inclusion period of 14 months. All patients were offered free of charge individually adjusted CPAP therapy. Data on comorbidity, medication, BMI and Epworth Sleepiness Score (ESS) were obtained by questionnaires and consultation with an otorhinolaryngeal specialist. RESULTS: The median follow-up time after initiating CPAP therapy was 3.0 (range 2.4–3.6) years. An adherence rate of 89% was found for severe OSA, 71% for moderate OSA and 55% for mild OSA. 18% initiated humidification. Patients adherent to CPAP had a significantly higher Body Mass Index (BMI), Apnea Hypopnea Index (AHI), Oxygen Desaturation Index (ODI) and ESS compared to non-adherent patients. Furthermore, adherence was associated with a higher frequency of observed interrupted breathing, a less frequent use of hypnotic drugs, fewer smokers, and they were more often offered humidification. Age, gender and comorbidity were not significantly associated with adherence. In a Cox model only AHI (Hazard Ratio (HR) 0.963, p < 0.001), ESS (HR 0.939, p = 0.001) and smoking (HR 1.576, p = 0.022) were independently associated with CPAP non-adherence. CONCLUSIONS: The severity of OSA, subjective daytime sleepiness and smoking status are independently related to adherence to CPAP therapy. Public Library of Science 2017-12-18 /pmc/articles/PMC5734784/ /pubmed/29253872 http://dx.doi.org/10.1371/journal.pone.0189614 Text en © 2017 Jacobsen et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Jacobsen, Anne Roed
Eriksen, Freja
Hansen, Rasmus Würgler
Erlandsen, Mogens
Thorup, Line
Damgård, Mette Bjerre
Kirkegaard, Martin Glümer
Hansen, Klavs Würgler
Determinants for adherence to continuous positive airway pressure therapy in obstructive sleep apnea
title Determinants for adherence to continuous positive airway pressure therapy in obstructive sleep apnea
title_full Determinants for adherence to continuous positive airway pressure therapy in obstructive sleep apnea
title_fullStr Determinants for adherence to continuous positive airway pressure therapy in obstructive sleep apnea
title_full_unstemmed Determinants for adherence to continuous positive airway pressure therapy in obstructive sleep apnea
title_short Determinants for adherence to continuous positive airway pressure therapy in obstructive sleep apnea
title_sort determinants for adherence to continuous positive airway pressure therapy in obstructive sleep apnea
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734784/
https://www.ncbi.nlm.nih.gov/pubmed/29253872
http://dx.doi.org/10.1371/journal.pone.0189614
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