MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma

ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. We identify ATG4B as a substrate of mammalian sterile20-like kinase (STK) 26/MST4. MST4 phosphorylates ATG4B at serine residue 383, which stimulates ATG4B activity and increases autophagic flux....

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Detalles Bibliográficos
Autores principales: Huang, Tianzhi, Kim, Chung Kwon, Alvarez, Angel A., Pangeni, Rajendra P., Wan, Xuechao, Song, Xiao, Shi, Taiping, Yang, Yongyong, Sastry, Namratha, Horbinski, Craig M., Lu, Songjian, Stupp, Roger, Kessler, John A., Nishikawa, Ryo, Nakano, Ichiro, Sulman, Erik P., Lu, Xinghua, James, Charles David, Yin, Xiao-Ming, Hu, Bo, Cheng, Shi-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734934/
https://www.ncbi.nlm.nih.gov/pubmed/29232556
http://dx.doi.org/10.1016/j.ccell.2017.11.005

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