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Long-lived tissue resident HIV-1 specific memory CD8(+) T cells are generated by skin immunization with live virus vectored microneedle arrays

The generation of tissue resident memory (T(RM)) cells at the body surfaces to provide a front line defence against invading pathogens represents an important goal in vaccine development for a wide variety of pathogens. It has been widely assumed that local vaccine delivery to the mucosae is necessa...

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Detalles Bibliográficos
Autores principales: Zaric, Marija, Becker, Pablo Daniel, Hervouet, Catherine, Kalcheva, Petya, Ibarzo Yus, Barbara, Cocita, Clement, O'Neill, Lauren Alexandra, Kwon, Sung-Yun, Klavinskis, Linda Sylvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Publishers 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735037/
https://www.ncbi.nlm.nih.gov/pubmed/29056444
http://dx.doi.org/10.1016/j.jconrel.2017.10.026