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Partial CD25 Antagonism Enables Dominance of Antigen-Inducible CD25(high) FOXP3(+) Regulatory T Cells As a Basis for a Regulatory T Cell-Based Adoptive Immunotherapy
FOXP3(+) regulatory T cells (Tregs) represent a promising platform for effective adoptive immunotherapy of chronic inflammatory disease, including autoimmune diseases such as multiple sclerosis. Successful Treg immunotherapy however requires new technologies to enable long-term expansion of stable,...
Autores principales: | Wilkinson, Daniel S., Ghosh, Debjani, Nickle, Rebecca A., Moorman, Cody D., Mannie, Mark D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735073/ https://www.ncbi.nlm.nih.gov/pubmed/29312311 http://dx.doi.org/10.3389/fimmu.2017.01782 |
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