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Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis

Aberrant activation of NLRP3 inflammasome has an important function in the pathogenesis of various inflammatory diseases. Although many components and mediators of inflammasome activation have been identified, how NLRP3 inflammasome is regulated to prevent excessive inflammation is unclear. Here we...

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Detalles Bibliográficos
Autores principales:	Guo, Wenjie, Liu, Wen, Chen, Zhen, Gu, Yanhong, Peng, Shuang, Shen, Lihong, Shen, Yan, Wang, Xingqi, Feng, Gen-Sheng, Sun, Yang, Xu, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735095/ https://www.ncbi.nlm.nih.gov/pubmed/29255148 http://dx.doi.org/10.1038/s41467-017-02351-0

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