Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer

Advanced-stage epithelial ovarian cancers are amongst the most difficult to treat tumors and have proven to be refractory to most cytotoxic, molecularly targeted, or immunotherapeutic approaches. Here, we report that nanoparticle-drug conjugates (NDCs) of monomethyl auristatin E (MMAE) significantly...

Descripción completa

Detalles Bibliográficos
Autores principales: Qi, Ruogu, Wang, Yongheng, Bruno, Peter M., Xiao, Haihua, Yu, Yingjie, Li, Ting, Lauffer, Sam, Wei, Wei, Chen, Qixian, Kang, Xiang, Song, Haiqin, Yang, Xi, Huang, Xing, Detappe, Alexandre, Matulonis, Ursula, Pepin, David, Hemann, Michael T., Birrer, Michael J., Ghoroghchian, P. Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735131/
https://www.ncbi.nlm.nih.gov/pubmed/29255160
http://dx.doi.org/10.1038/s41467-017-02390-7

Ejemplares similares

Ejemplares similares