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Evidence for hippocampal dependence of value-based decisions

Consistent decisions are intuitively desirable and theoretically important for utility maximization. Neuroeconomics has established the neurobiological substrate of value representation, but brain regions that provide input to this network is less explored. The constructed-preference tradition withi...

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Autores principales: Enkavi, A. Zeynep, Weber, Bernd, Zweyer, Iris, Wagner, Jan, Elger, Christian E., Weber, Elke U., Johnson, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735154/
https://www.ncbi.nlm.nih.gov/pubmed/29255296
http://dx.doi.org/10.1038/s41598-017-18015-4
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author Enkavi, A. Zeynep
Weber, Bernd
Zweyer, Iris
Wagner, Jan
Elger, Christian E.
Weber, Elke U.
Johnson, Eric J.
author_facet Enkavi, A. Zeynep
Weber, Bernd
Zweyer, Iris
Wagner, Jan
Elger, Christian E.
Weber, Elke U.
Johnson, Eric J.
author_sort Enkavi, A. Zeynep
collection PubMed
description Consistent decisions are intuitively desirable and theoretically important for utility maximization. Neuroeconomics has established the neurobiological substrate of value representation, but brain regions that provide input to this network is less explored. The constructed-preference tradition within behavioral decision research gives a critical role to associative cognitive processes, suggesting a hippocampal role in making consistent decisions. We compared the performance of 31 patients with mediotemporal lobe (MTL) epilepsy and hippocampal lesions, 30 patients with extratemporal lobe epilepsy, and 30 healthy controls on two tasks: binary choices between candy bars based on their preferences and a number-comparison control task where the larger number is chosen. MTL patients made more inconsistent choices than the other two groups for the value-based choice but not the number-comparison task. These inconsistencies correlated with the volume of compromised hippocampal tissue. These results add to increasing evidence on a critical involvement of the MTL in preference construction and value-based choices.
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spelling pubmed-57351542017-12-21 Evidence for hippocampal dependence of value-based decisions Enkavi, A. Zeynep Weber, Bernd Zweyer, Iris Wagner, Jan Elger, Christian E. Weber, Elke U. Johnson, Eric J. Sci Rep Article Consistent decisions are intuitively desirable and theoretically important for utility maximization. Neuroeconomics has established the neurobiological substrate of value representation, but brain regions that provide input to this network is less explored. The constructed-preference tradition within behavioral decision research gives a critical role to associative cognitive processes, suggesting a hippocampal role in making consistent decisions. We compared the performance of 31 patients with mediotemporal lobe (MTL) epilepsy and hippocampal lesions, 30 patients with extratemporal lobe epilepsy, and 30 healthy controls on two tasks: binary choices between candy bars based on their preferences and a number-comparison control task where the larger number is chosen. MTL patients made more inconsistent choices than the other two groups for the value-based choice but not the number-comparison task. These inconsistencies correlated with the volume of compromised hippocampal tissue. These results add to increasing evidence on a critical involvement of the MTL in preference construction and value-based choices. Nature Publishing Group UK 2017-12-18 /pmc/articles/PMC5735154/ /pubmed/29255296 http://dx.doi.org/10.1038/s41598-017-18015-4 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Enkavi, A. Zeynep
Weber, Bernd
Zweyer, Iris
Wagner, Jan
Elger, Christian E.
Weber, Elke U.
Johnson, Eric J.
Evidence for hippocampal dependence of value-based decisions
title Evidence for hippocampal dependence of value-based decisions
title_full Evidence for hippocampal dependence of value-based decisions
title_fullStr Evidence for hippocampal dependence of value-based decisions
title_full_unstemmed Evidence for hippocampal dependence of value-based decisions
title_short Evidence for hippocampal dependence of value-based decisions
title_sort evidence for hippocampal dependence of value-based decisions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735154/
https://www.ncbi.nlm.nih.gov/pubmed/29255296
http://dx.doi.org/10.1038/s41598-017-18015-4
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