Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites

The catalytic domain of protein tyrosine kinases can interconvert between active and inactive conformations in response to regulatory inputs. We recently demonstrated that Src kinase features an allosteric network that couples substrate-binding sites. However, the extent of conformational and dynami...

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Detalles Bibliográficos
Autores principales: Tong, Michael, Pelton, Jeff G., Gill, Michelle L., Zhang, Weibing, Picart, Francis, Seeliger, Markus A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735167/
https://www.ncbi.nlm.nih.gov/pubmed/29255153
http://dx.doi.org/10.1038/s41467-017-02240-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735167/
https://www.ncbi.nlm.nih.gov/pubmed/29255153
http://dx.doi.org/10.1038/s41467-017-02240-6

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