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Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites
The catalytic domain of protein tyrosine kinases can interconvert between active and inactive conformations in response to regulatory inputs. We recently demonstrated that Src kinase features an allosteric network that couples substrate-binding sites. However, the extent of conformational and dynami...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735167/ https://www.ncbi.nlm.nih.gov/pubmed/29255153 http://dx.doi.org/10.1038/s41467-017-02240-6 |