PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle

Facioscapulohumeral muscular dystrophy (FSHD) is a prevalent, incurable myopathy, linked to hypomethylation of D4Z4 repeats on chromosome 4q causing expression of the DUX4 transcription factor. However, DUX4 is difficult to detect in FSHD muscle biopsies and it is debatable how robust changes in DUX...

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Detalles Bibliográficos
Autores principales: Banerji, Christopher R. S., Panamarova, Maryna, Hebaishi, Husam, White, Robert B., Relaix, Frédéric, Severini, Simone, Zammit, Peter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735185/
https://www.ncbi.nlm.nih.gov/pubmed/29255294
http://dx.doi.org/10.1038/s41467-017-01200-4

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