Expression of a specific extracellular matrix signature is a favorable prognostic factor in acute myeloid leukemia

Relapse of acute myeloid leukemia (AML) is still dramatically frequent, imposing the need for early markers to quantify such risk. Recent evidence point to a prominent role for extracellular matrix (ECM) in AML, but its prognostic value has not yet been investigated. Here we have investigated whethe...

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Autores principales: Izzi, Valerio, Lakkala, Juho, Devarajan, Raman, Savolainen, Eeva-Riitta, Koistinen, Pirjo, Heljasvaara, Ritva, Pihlajaniemi, Taina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735295/
https://www.ncbi.nlm.nih.gov/pubmed/29270355
http://dx.doi.org/10.1016/j.lrr.2017.12.001
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author Izzi, Valerio
Lakkala, Juho
Devarajan, Raman
Savolainen, Eeva-Riitta
Koistinen, Pirjo
Heljasvaara, Ritva
Pihlajaniemi, Taina
author_facet Izzi, Valerio
Lakkala, Juho
Devarajan, Raman
Savolainen, Eeva-Riitta
Koistinen, Pirjo
Heljasvaara, Ritva
Pihlajaniemi, Taina
author_sort Izzi, Valerio
collection PubMed
description Relapse of acute myeloid leukemia (AML) is still dramatically frequent, imposing the need for early markers to quantify such risk. Recent evidence point to a prominent role for extracellular matrix (ECM) in AML, but its prognostic value has not yet been investigated. Here we have investigated whether the expression of a 15-ECM gene signature could be applied to clinical AML research evaluating a retrospective cohort of 61 AML patients and 12 healthy donors. Results show that patients whose ECM signature expression is at least twice as that of healthy donors have considerably longer relapse-free survival, with further stage-specific therapy outcomes.
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spelling pubmed-57352952017-12-21 Expression of a specific extracellular matrix signature is a favorable prognostic factor in acute myeloid leukemia Izzi, Valerio Lakkala, Juho Devarajan, Raman Savolainen, Eeva-Riitta Koistinen, Pirjo Heljasvaara, Ritva Pihlajaniemi, Taina Leuk Res Rep Article Relapse of acute myeloid leukemia (AML) is still dramatically frequent, imposing the need for early markers to quantify such risk. Recent evidence point to a prominent role for extracellular matrix (ECM) in AML, but its prognostic value has not yet been investigated. Here we have investigated whether the expression of a 15-ECM gene signature could be applied to clinical AML research evaluating a retrospective cohort of 61 AML patients and 12 healthy donors. Results show that patients whose ECM signature expression is at least twice as that of healthy donors have considerably longer relapse-free survival, with further stage-specific therapy outcomes. Elsevier 2017-12-13 /pmc/articles/PMC5735295/ /pubmed/29270355 http://dx.doi.org/10.1016/j.lrr.2017.12.001 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Izzi, Valerio
Lakkala, Juho
Devarajan, Raman
Savolainen, Eeva-Riitta
Koistinen, Pirjo
Heljasvaara, Ritva
Pihlajaniemi, Taina
Expression of a specific extracellular matrix signature is a favorable prognostic factor in acute myeloid leukemia
title Expression of a specific extracellular matrix signature is a favorable prognostic factor in acute myeloid leukemia
title_full Expression of a specific extracellular matrix signature is a favorable prognostic factor in acute myeloid leukemia
title_fullStr Expression of a specific extracellular matrix signature is a favorable prognostic factor in acute myeloid leukemia
title_full_unstemmed Expression of a specific extracellular matrix signature is a favorable prognostic factor in acute myeloid leukemia
title_short Expression of a specific extracellular matrix signature is a favorable prognostic factor in acute myeloid leukemia
title_sort expression of a specific extracellular matrix signature is a favorable prognostic factor in acute myeloid leukemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735295/
https://www.ncbi.nlm.nih.gov/pubmed/29270355
http://dx.doi.org/10.1016/j.lrr.2017.12.001
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