Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer

[Image: see text] An optimized large scale and highly reproducible route to orthogonally protected γ-thiolysine is reported. Its utility in the synthesis of bifunctional ubiquitin monomers is demonstrated. These ubiquitin synthons are employed in polymerization reactions giving access to synthetic p...

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Detalles Bibliográficos
Autores principales: van der Heden van Noort, Gerbrand J., Kooij, Raymond, Elliott, Paul R., Komander, David, Ovaa, Huib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735377/
https://www.ncbi.nlm.nih.gov/pubmed/29172548
http://dx.doi.org/10.1021/acs.orglett.7b03085
Descripción
Sumario:[Image: see text] An optimized large scale and highly reproducible route to orthogonally protected γ-thiolysine is reported. Its utility in the synthesis of bifunctional ubiquitin monomers is demonstrated. These ubiquitin synthons are employed in polymerization reactions giving access to synthetic poly-ubiquitin chains of defined linkage.

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