Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer

[Image: see text] An optimized large scale and highly reproducible route to orthogonally protected γ-thiolysine is reported. Its utility in the synthesis of bifunctional ubiquitin monomers is demonstrated. These ubiquitin synthons are employed in polymerization reactions giving access to synthetic p...

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Autores principales: van der Heden van Noort, Gerbrand J., Kooij, Raymond, Elliott, Paul R., Komander, David, Ovaa, Huib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735377/
https://www.ncbi.nlm.nih.gov/pubmed/29172548
http://dx.doi.org/10.1021/acs.orglett.7b03085
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author van der Heden van Noort, Gerbrand J.
Kooij, Raymond
Elliott, Paul R.
Komander, David
Ovaa, Huib
author_facet van der Heden van Noort, Gerbrand J.
Kooij, Raymond
Elliott, Paul R.
Komander, David
Ovaa, Huib
author_sort van der Heden van Noort, Gerbrand J.
collection PubMed
description [Image: see text] An optimized large scale and highly reproducible route to orthogonally protected γ-thiolysine is reported. Its utility in the synthesis of bifunctional ubiquitin monomers is demonstrated. These ubiquitin synthons are employed in polymerization reactions giving access to synthetic poly-ubiquitin chains of defined linkage.
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spelling pubmed-57353772017-12-26 Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer van der Heden van Noort, Gerbrand J. Kooij, Raymond Elliott, Paul R. Komander, David Ovaa, Huib Org Lett [Image: see text] An optimized large scale and highly reproducible route to orthogonally protected γ-thiolysine is reported. Its utility in the synthesis of bifunctional ubiquitin monomers is demonstrated. These ubiquitin synthons are employed in polymerization reactions giving access to synthetic poly-ubiquitin chains of defined linkage. American Chemical Society 2017-11-27 2017-12-15 /pmc/articles/PMC5735377/ /pubmed/29172548 http://dx.doi.org/10.1021/acs.orglett.7b03085 Text en Copyright © 2017 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle van der Heden van Noort, Gerbrand J.
Kooij, Raymond
Elliott, Paul R.
Komander, David
Ovaa, Huib
Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer
title Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer
title_full Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer
title_fullStr Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer
title_full_unstemmed Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer
title_short Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer
title_sort synthesis of poly-ubiquitin chains using a bifunctional ubiquitin monomer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735377/
https://www.ncbi.nlm.nih.gov/pubmed/29172548
http://dx.doi.org/10.1021/acs.orglett.7b03085
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