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Intrathecal Hyperbaric Bupivacaine with Varying Doses of Buprenorphine for Postoperative Analgesia after Cesarean Section: A Comparative Study

BACKGROUND: Postoperative analgesia after cesarean section poses unique clinical challenges to anesthesiologist. Intrathecal buprenorphine is a promising drug for postoperative analgesia. AIM: The aim of this study was to compare the efficacy of two doses of buprenorphine (45 μg and 60 μg) as an adj...

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Autores principales: Ravindran, Rashmi, Sajid, Binu, Ramadas, Konnanath Thekkethil, Susheela, Indu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735494/
https://www.ncbi.nlm.nih.gov/pubmed/29284855
http://dx.doi.org/10.4103/aer.AER_82_17
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author Ravindran, Rashmi
Sajid, Binu
Ramadas, Konnanath Thekkethil
Susheela, Indu
author_facet Ravindran, Rashmi
Sajid, Binu
Ramadas, Konnanath Thekkethil
Susheela, Indu
author_sort Ravindran, Rashmi
collection PubMed
description BACKGROUND: Postoperative analgesia after cesarean section poses unique clinical challenges to anesthesiologist. Intrathecal buprenorphine is a promising drug for postoperative analgesia. AIM: The aim of this study was to compare the efficacy of two doses of buprenorphine (45 μg and 60 μg) as an adjuvant to hyperbaric bupivacaine for postoperative analgesia in cesarean section. SETTING AND DESIGN: Prospective randomized double-blind controlled study involving ninety parturients posted for elective cesarean section under subarachnoid block. MATERIALS AND METHODS: Group A (n = 30) received 1.8 ml of 0.5% hyperbaric bupivacaine with 45 μg buprenorphine, Group B (n = 30) received 1.8 ml 0.5% hyperbaric bupivacaine with 60 μg buprenorphine, Group C (n = 30) received 1.8 ml of 0.5% hyperbaric bupivacaine with 0.2 ml normal saline, respectively. Following parameters were observed: onset and duration of sensory block, postoperative pain scores based on visual analog scale (VAS), rescue analgesic requirement, and maternal and neonatal side effects if any. STATISTICAL ANALYSIS: Unpaired t-test and Chi-square test were used. RESULTS: Duration of postoperative analgesia was significantly prolonged in Groups A and B in comparison to Group C and it was longest in Group B. Rescue analgesic requirement and VAS score were significantly lower in the buprenorphine groups. No major side effects were observed. CONCLUSION: Addition of buprenorphine to intrathecal bupivacaine prolonged the duration and quality of postoperative analgesia after cesarean section. Increasing the dose of buprenorphine from 45 μg to 60 μg provided longer duration of analgesia without increase in adverse effects.
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spelling pubmed-57354942017-12-28 Intrathecal Hyperbaric Bupivacaine with Varying Doses of Buprenorphine for Postoperative Analgesia after Cesarean Section: A Comparative Study Ravindran, Rashmi Sajid, Binu Ramadas, Konnanath Thekkethil Susheela, Indu Anesth Essays Res Original Article BACKGROUND: Postoperative analgesia after cesarean section poses unique clinical challenges to anesthesiologist. Intrathecal buprenorphine is a promising drug for postoperative analgesia. AIM: The aim of this study was to compare the efficacy of two doses of buprenorphine (45 μg and 60 μg) as an adjuvant to hyperbaric bupivacaine for postoperative analgesia in cesarean section. SETTING AND DESIGN: Prospective randomized double-blind controlled study involving ninety parturients posted for elective cesarean section under subarachnoid block. MATERIALS AND METHODS: Group A (n = 30) received 1.8 ml of 0.5% hyperbaric bupivacaine with 45 μg buprenorphine, Group B (n = 30) received 1.8 ml 0.5% hyperbaric bupivacaine with 60 μg buprenorphine, Group C (n = 30) received 1.8 ml of 0.5% hyperbaric bupivacaine with 0.2 ml normal saline, respectively. Following parameters were observed: onset and duration of sensory block, postoperative pain scores based on visual analog scale (VAS), rescue analgesic requirement, and maternal and neonatal side effects if any. STATISTICAL ANALYSIS: Unpaired t-test and Chi-square test were used. RESULTS: Duration of postoperative analgesia was significantly prolonged in Groups A and B in comparison to Group C and it was longest in Group B. Rescue analgesic requirement and VAS score were significantly lower in the buprenorphine groups. No major side effects were observed. CONCLUSION: Addition of buprenorphine to intrathecal bupivacaine prolonged the duration and quality of postoperative analgesia after cesarean section. Increasing the dose of buprenorphine from 45 μg to 60 μg provided longer duration of analgesia without increase in adverse effects. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5735494/ /pubmed/29284855 http://dx.doi.org/10.4103/aer.AER_82_17 Text en Copyright: © 2017 Anesthesia: Essays and Researches http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Ravindran, Rashmi
Sajid, Binu
Ramadas, Konnanath Thekkethil
Susheela, Indu
Intrathecal Hyperbaric Bupivacaine with Varying Doses of Buprenorphine for Postoperative Analgesia after Cesarean Section: A Comparative Study
title Intrathecal Hyperbaric Bupivacaine with Varying Doses of Buprenorphine for Postoperative Analgesia after Cesarean Section: A Comparative Study
title_full Intrathecal Hyperbaric Bupivacaine with Varying Doses of Buprenorphine for Postoperative Analgesia after Cesarean Section: A Comparative Study
title_fullStr Intrathecal Hyperbaric Bupivacaine with Varying Doses of Buprenorphine for Postoperative Analgesia after Cesarean Section: A Comparative Study
title_full_unstemmed Intrathecal Hyperbaric Bupivacaine with Varying Doses of Buprenorphine for Postoperative Analgesia after Cesarean Section: A Comparative Study
title_short Intrathecal Hyperbaric Bupivacaine with Varying Doses of Buprenorphine for Postoperative Analgesia after Cesarean Section: A Comparative Study
title_sort intrathecal hyperbaric bupivacaine with varying doses of buprenorphine for postoperative analgesia after cesarean section: a comparative study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735494/
https://www.ncbi.nlm.nih.gov/pubmed/29284855
http://dx.doi.org/10.4103/aer.AER_82_17
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