Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

BACKGROUND: Myeloid cells are an abundant leukocyte in many types of tumors and contribute to immune evasion. Expression of the enzyme arginase 1 (Arg1) is a defining feature of immunosuppressive myeloid cells and leads to depletion of L-arginine, a nutrient required for T cell and natural killer (N...

Descripción completa

Detalles Bibliográficos
Autores principales: Steggerda, Susanne M., Bennett, Mark K., Chen, Jason, Emberley, Ethan, Huang, Tony, Janes, Julie R., Li, Weiqun, MacKinnon, Andrew L., Makkouk, Amani, Marguier, Gisele, Murray, Peter J., Neou, Silinda, Pan, Alison, Parlati, Francesco, Rodriguez, Mirna L. M., Van de Velde, Lee-Ann, Wang, Tracy, Works, Melissa, Zhang, Jing, Zhang, Winter, Gross, Matthew I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735564/
https://www.ncbi.nlm.nih.gov/pubmed/29254508
http://dx.doi.org/10.1186/s40425-017-0308-4

Ejemplares similares

Ejemplares similares