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Cognitive Impact of Deep Brain Stimulation on Parkinson's Disease Patients

Subthalamic nucleus (STN) or globus pallidus interna (GPi) deep brain stimulation (DBS) is considered a robust therapeutic tool in the treatment of Parkinson's disease (PD) patients, although it has been reported to potentially cause cognitive decline in some cases. We here provide an in-depth...

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Autores principales: Mehanna, Raja, Bajwa, Jawad A., Fernandez, Hubert, Wagle Shukla, Aparna Ashutosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735627/
https://www.ncbi.nlm.nih.gov/pubmed/29359065
http://dx.doi.org/10.1155/2017/3085140
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author Mehanna, Raja
Bajwa, Jawad A.
Fernandez, Hubert
Wagle Shukla, Aparna Ashutosh
author_facet Mehanna, Raja
Bajwa, Jawad A.
Fernandez, Hubert
Wagle Shukla, Aparna Ashutosh
author_sort Mehanna, Raja
collection PubMed
description Subthalamic nucleus (STN) or globus pallidus interna (GPi) deep brain stimulation (DBS) is considered a robust therapeutic tool in the treatment of Parkinson's disease (PD) patients, although it has been reported to potentially cause cognitive decline in some cases. We here provide an in-depth and critical review of the current literature regarding cognition after DBS in PD, summarizing the available data on the impact of STN and GPi DBS as monotherapies and also comparative data across these two therapies on 7 cognitive domains. We provide evidence that, in appropriately screened PD patients, worsening of one or more cognitive functions is rare and subtle after DBS, without negative impact on quality of life, and that there is very little data supporting that STN DBS has a worse cognitive outcome than GPi DBS.
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spelling pubmed-57356272018-01-22 Cognitive Impact of Deep Brain Stimulation on Parkinson's Disease Patients Mehanna, Raja Bajwa, Jawad A. Fernandez, Hubert Wagle Shukla, Aparna Ashutosh Parkinsons Dis Review Article Subthalamic nucleus (STN) or globus pallidus interna (GPi) deep brain stimulation (DBS) is considered a robust therapeutic tool in the treatment of Parkinson's disease (PD) patients, although it has been reported to potentially cause cognitive decline in some cases. We here provide an in-depth and critical review of the current literature regarding cognition after DBS in PD, summarizing the available data on the impact of STN and GPi DBS as monotherapies and also comparative data across these two therapies on 7 cognitive domains. We provide evidence that, in appropriately screened PD patients, worsening of one or more cognitive functions is rare and subtle after DBS, without negative impact on quality of life, and that there is very little data supporting that STN DBS has a worse cognitive outcome than GPi DBS. Hindawi 2017 2017-11-22 /pmc/articles/PMC5735627/ /pubmed/29359065 http://dx.doi.org/10.1155/2017/3085140 Text en Copyright © 2017 Raja Mehanna et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mehanna, Raja
Bajwa, Jawad A.
Fernandez, Hubert
Wagle Shukla, Aparna Ashutosh
Cognitive Impact of Deep Brain Stimulation on Parkinson's Disease Patients
title Cognitive Impact of Deep Brain Stimulation on Parkinson's Disease Patients
title_full Cognitive Impact of Deep Brain Stimulation on Parkinson's Disease Patients
title_fullStr Cognitive Impact of Deep Brain Stimulation on Parkinson's Disease Patients
title_full_unstemmed Cognitive Impact of Deep Brain Stimulation on Parkinson's Disease Patients
title_short Cognitive Impact of Deep Brain Stimulation on Parkinson's Disease Patients
title_sort cognitive impact of deep brain stimulation on parkinson's disease patients
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735627/
https://www.ncbi.nlm.nih.gov/pubmed/29359065
http://dx.doi.org/10.1155/2017/3085140
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