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SERINC as a Restriction Factor to Inhibit Viral Infectivity and the Interaction with HIV

The serine incorporator 5 (SERINC5) is a recently discovered restriction factor that inhibits viral infectivity by preventing fusion. Retroviruses have developed strategies to counteract the action of SERINC5, such as the expression of proteins like negative regulatory factor (Nef), S2, and glycosyl...

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Autores principales: Gonzalez-Enriquez, Gracia Viviana, Escoto-Delgadillo, Martha, Vazquez-Valls, Eduardo, Torres-Mendoza, Blanca Miriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735641/
https://www.ncbi.nlm.nih.gov/pubmed/29359168
http://dx.doi.org/10.1155/2017/1548905
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author Gonzalez-Enriquez, Gracia Viviana
Escoto-Delgadillo, Martha
Vazquez-Valls, Eduardo
Torres-Mendoza, Blanca Miriam
author_facet Gonzalez-Enriquez, Gracia Viviana
Escoto-Delgadillo, Martha
Vazquez-Valls, Eduardo
Torres-Mendoza, Blanca Miriam
author_sort Gonzalez-Enriquez, Gracia Viviana
collection PubMed
description The serine incorporator 5 (SERINC5) is a recently discovered restriction factor that inhibits viral infectivity by preventing fusion. Retroviruses have developed strategies to counteract the action of SERINC5, such as the expression of proteins like negative regulatory factor (Nef), S2, and glycosylated Gag (glycoGag). These accessory proteins downregulate SERINC5 from the plasma membrane for subsequent degradation in the lysosomes. The observed variability in the action of SERINC5 suggests the participation of other elements like the envelope glycoprotein (Env) that modulates susceptibility of the virus towards SERINC5. The exact mechanism by which SERINC5 inhibits viral fusion has not yet been determined, although it has been proposed that it increases the sensitivity of the Env by exposing regions which are recognized by neutralizing antibodies. More studies are needed to understand the role of SERINC5 and to assess its utility as a therapeutic strategy.
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spelling pubmed-57356412018-01-22 SERINC as a Restriction Factor to Inhibit Viral Infectivity and the Interaction with HIV Gonzalez-Enriquez, Gracia Viviana Escoto-Delgadillo, Martha Vazquez-Valls, Eduardo Torres-Mendoza, Blanca Miriam J Immunol Res Review Article The serine incorporator 5 (SERINC5) is a recently discovered restriction factor that inhibits viral infectivity by preventing fusion. Retroviruses have developed strategies to counteract the action of SERINC5, such as the expression of proteins like negative regulatory factor (Nef), S2, and glycosylated Gag (glycoGag). These accessory proteins downregulate SERINC5 from the plasma membrane for subsequent degradation in the lysosomes. The observed variability in the action of SERINC5 suggests the participation of other elements like the envelope glycoprotein (Env) that modulates susceptibility of the virus towards SERINC5. The exact mechanism by which SERINC5 inhibits viral fusion has not yet been determined, although it has been proposed that it increases the sensitivity of the Env by exposing regions which are recognized by neutralizing antibodies. More studies are needed to understand the role of SERINC5 and to assess its utility as a therapeutic strategy. Hindawi 2017 2017-11-22 /pmc/articles/PMC5735641/ /pubmed/29359168 http://dx.doi.org/10.1155/2017/1548905 Text en Copyright © 2017 Gracia Viviana Gonzalez-Enriquez et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gonzalez-Enriquez, Gracia Viviana
Escoto-Delgadillo, Martha
Vazquez-Valls, Eduardo
Torres-Mendoza, Blanca Miriam
SERINC as a Restriction Factor to Inhibit Viral Infectivity and the Interaction with HIV
title SERINC as a Restriction Factor to Inhibit Viral Infectivity and the Interaction with HIV
title_full SERINC as a Restriction Factor to Inhibit Viral Infectivity and the Interaction with HIV
title_fullStr SERINC as a Restriction Factor to Inhibit Viral Infectivity and the Interaction with HIV
title_full_unstemmed SERINC as a Restriction Factor to Inhibit Viral Infectivity and the Interaction with HIV
title_short SERINC as a Restriction Factor to Inhibit Viral Infectivity and the Interaction with HIV
title_sort serinc as a restriction factor to inhibit viral infectivity and the interaction with hiv
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735641/
https://www.ncbi.nlm.nih.gov/pubmed/29359168
http://dx.doi.org/10.1155/2017/1548905
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