Cargando…

Streptococcal toxic shock syndrome caused by the dissemination of an invasive emm3/ST15 strain of Streptococcus pyogenes

BACKGROUND: Streptococcus pyogenes (group A Streptococcus [GAS]) is a major human pathogen that causes a wide spectrum of clinical manifestations. Although invasive GAS (iGAS) infections are relatively uncommon, emm3/ST15 GAS is a highly virulent, invasive, and pathogenic strain. Global molecular ep...

Descripción completa

Detalles Bibliográficos
Autores principales: Sekizuka, Tsuyoshi, Nai, Emina, Yoshida, Tomohiro, Endo, Shota, Hamajima, Emi, Akiyama, Satoka, Ikuta, Yoji, Obana, Natsuko, Kawaguchi, Takahiro, Hayashi, Kenta, Noda, Masahiro, Sumita, Tomoko, Kokaji, Masayuki, Katori, Tatsuo, Hashino, Masanori, Oba, Kunihiro, Kuroda, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735678/
https://www.ncbi.nlm.nih.gov/pubmed/29254479
http://dx.doi.org/10.1186/s12879-017-2870-2
Descripción
Sumario:BACKGROUND: Streptococcus pyogenes (group A Streptococcus [GAS]) is a major human pathogen that causes a wide spectrum of clinical manifestations. Although invasive GAS (iGAS) infections are relatively uncommon, emm3/ST15 GAS is a highly virulent, invasive, and pathogenic strain. Global molecular epidemiology analysis has suggested that the frequency of emm3 GAS has been recently increasing. CASE PRESENTATION: A 14-year-old patient was diagnosed with streptococcal toxic shock syndrome and severe pneumonia, impaired renal function, and rhabdomyolysis. GAS was isolated from a culture of endotracheal aspirates and designated as KS030. Comparative genome analysis suggested that KS030 is classified as emm3 (emm-type) and ST15 (multilocus sequencing typing [MLST]), which is similar to iGAS isolates identified in the UK (2013) and Switzerland (2015). CONCLUSIONS: We conclude that the global dissemination of emm3/ST15 GAS strain has the potential to cause invasive disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12879-017-2870-2) contains supplementary material, which is available to authorized users.