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Encoding optical control in LCK kinase to quantitatively investigate its activity in live cells

LCK is a tyrosine kinase essential for initiating T-cell antigen receptor (TCR) signaling. A complete understanding of LCK function is constrained by a paucity of methods to quantitatively study its function within live cells. To address this limitation, we generated LCK*, in which a key active site...

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Detalles Bibliográficos
Autores principales:	Liaunardy-Jopeace, Ardiyanto, Murton, Ben L, Mahesh, Mohan, Chin, Jason W, James, John R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736103/ https://www.ncbi.nlm.nih.gov/pubmed/29083415 http://dx.doi.org/10.1038/nsmb.3492

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