Cargando…

Encoding optical control in LCK kinase to quantitatively investigate its activity in live cells

LCK is a tyrosine kinase essential for initiating T-cell antigen receptor (TCR) signaling. A complete understanding of LCK function is constrained by a paucity of methods to quantitatively study its function within live cells. To address this limitation, we generated LCK*, in which a key active site...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liaunardy-Jopeace, Ardiyanto, Murton, Ben L, Mahesh, Mohan, Chin, Jason W, James, John R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736103/ https://www.ncbi.nlm.nih.gov/pubmed/29083415 http://dx.doi.org/10.1038/nsmb.3492

Ejemplares similares

Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56(Lck) regulates T-cell activation independently of Lck/CD45 interactions
por: Kästle, Matthias, et al.
Publicado: (2020)

Molecular and Cellular Regulation of Toll-Like Receptor-4 Activity Induced by Lipopolysaccharide Ligands
por: Liaunardy-Jopeace, Ardiyanto, et al.
Publicado: (2014)

Direct Observation and Quantitative Analysis of Lck Exchange between Plasma Membrane and Cytosol in Living T Cells
por: Zimmermann, Lars, et al.
Publicado: (2010)

Lck bound to coreceptor is less active than free Lck
por: Wei, Qianru, et al.
Publicado: (2020)

Tyrosine Phosphorylation of Tau by the Src Family Kinases Lck and Fyn
por: Scales, Timothy ME, et al.
Publicado: (2011)

Nilotinib inhibits the Src-family kinase LCK and T-cell function in vitro
por: Blake, Stephen J, et al.
Publicado: (2009)

Predictive Model of Lymphocyte-Specific Protein Tyrosine Kinase (LCK) Autoregulation
por: Rohrs, Jennifer A., et al.
Publicado: (2016)

Genetic Loss of LCK Kinase Leads to Acceleration of Chronic Lymphocytic Leukemia
por: Märklin, Melanie, et al.
Publicado: (2020)

p56lck interacts via its src homology 2 domain with the ZAP-70 kinase
Publicado: (1994)

Biophysical basis underlying dynamic Lck activation visualized by ZapLck FRET biosensor
por: Wan, Rongxue, et al.
Publicado: (2019)

The Lck Paradox: Because of Inconsistent Experimental Evidence, the Role of the Protein Tyrosine Kinase p(56)(lck) in Early Thymic Development Remains Poorly Defined
por: Eichmann, Klaus
Publicado: (1998)

Autophosphorylation and the Dynamics of the Activation of Lck
por: Kreusser, Lisa Maria, et al.
Publicado: (2021)

Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes
Publicado: (1994)

Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction
por: Nika, Konstantina, et al.
Publicado: (2010)

Genetic Encoding of Photocaged Cysteine Allows Photoactivation of TEV Protease in Live Mammalian Cells
por: Nguyen, Duy P., et al.
Publicado: (2014)

Roles of the Src Tyrosine Kinases Lck and Fyn in Regulating γδTCR Signal Strength
por: Laird, Renee M., et al.
Publicado: (2010)

The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation
por: Marhäll, Alissa, et al.
Publicado: (2017)

Lck activation: puzzling the pieces together
por: Simeoni, Luca
Publicado: (2017)

TCR Triggering Induces the Formation of Lck–RACK1–Actinin-1 Multiprotein Network Affecting Lck Redistribution
por: Ballek, Ondřej, et al.
Publicado: (2016)

The Tyrosine Kinase p56(lck) Mediates Activation of Swelling-induced Chloride Channels in Lymphocytes
por: Lepple-Wienhues, Albrecht, et al.
Publicado: (1998)

Requirement for p56lck tyrosine kinase activation in T cell receptor- mediated thymic selection
Publicado: (1996)

How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism
por: Rossy, Jérémie, et al.
Publicado: (2012)

Developmental regulation of lck gene expression in T lymphocytes
Publicado: (1991)

Role of the membrane anchor in the regulation of Lck activity
por: Porciello, Nicla, et al.
Publicado: (2022)

Accumulation of p60(lck) in HTLV‐I‐transformed T Cell Lines Detected by an Anti‐Lck Monoclonal Antibody, MOL 171
por: Moroi, Yoichi, et al.
Publicado: (1991)

LCK-SafeScreen-Model: An Advanced Ensemble Machine Learning Approach for Estimating the Binding Affinity between Compounds and LCK Target
por: Cheng, Ying, et al.
Publicado: (2023)

Association of the tyrosine kinase LCK with phospholipase C-gamma 1 after stimulation of the T cell antigen receptor
Publicado: (1992)

CD8 beta chain influences CD8 alpha chain-associated Lck kinase activity
Publicado: (1995)

Lck tyrosine kinase mediates β1-integrin signalling to regulate Schwann cell migration and myelination
por: Ness, Jennifer K., et al.
Publicado: (2013)

Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases
por: Sripada, Anand, et al.
Publicado: (2021)

Molecular dynamics simulations reveal membrane lipid interactions of the full-length lymphocyte specific kinase (Lck)
por: Prakaash, Dheeraj, et al.
Publicado: (2022)

Centrosome docking at the immunological synapse is controlled by Lck signaling
por: Tsun, Andy, et al.
Publicado: (2011)

Coclustering CD45 with CD4 or CD8 alters the phosphorylation and kinase activity of p56lck
Publicado: (1990)

A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling
por: Schultz, Annika, et al.
Publicado: (2022)

Identification and Characterization of the Amphioxus Lck and Its Associated Tyrosine Phosphorylation-Dependent Inhibitory LRR Receptor
por: Zhou, Jiatao, et al.
Publicado: (2021)

Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen
por: Shah, Neel H, et al.
Publicado: (2018)

CD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance
por: Wu, Ling, et al.
Publicado: (2023)

A Story of Kinases and Adaptors: The Role of Lck, ZAP-70 and LAT in Switch Panel Governing T-Cell Development and Activation
por: Fernández-Aguilar, Luis M., et al.
Publicado: (2023)

Regulation of Fyn Through Translocation of Activated Lck into Lipid Rafts
por: Filipp, Dominik, et al.
Publicado: (2003)

Distinct Mechanisms Regulate Lck Spatial Organization in Activated T Cells
por: Kapoor-Kaushik, Natasha, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_kmfakgmok9cc4e6lu37q4vijnt