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A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats

Neuroinflammation is potentiated by early degeneration of the locus coeruleus noradrenergic pathway (LC-NE) commonly seen in aging-related neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. In animal models, lipopolysaccharide (LPS) induces strong peripheral immune respo...

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Detalles Bibliográficos
Autores principales:	Bharani, Krishna L., Derex, Rebecca, Granholm, Ann-Charlotte, Ledreux, Aurélie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736222/ https://www.ncbi.nlm.nih.gov/pubmed/29261743 http://dx.doi.org/10.1371/journal.pone.0189821

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