HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage

Understanding how broadly neutralizing antibodies (bnAbs) to HIV envelope (Env) develop during natural infection can help guide the rational design of an HIV vaccine. Here, we described a bnAb lineage targeting the Env V2 apex and the Ab-Env co-evolution that led to development of neutralization bre...

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Detalles Bibliográficos
Autores principales: Landais, Elise, Murrell, Ben, Briney, Bryan, Murrell, Sasha, Rantalainen, Kimmo, Berndsen, Zachary T., Ramos, Alejandra, Wickramasinghe, Lalinda, Smith, Melissa Laird, Eren, Kemal, de Val, Natalia, Wu, Mengyu, Cappelletti, Audrey, Umotoy, Jeffrey, Lie, Yolanda, Wrin, Terri, Algate, Paul, Chan-Hui, Po-Ying, Karita, Etienne, Ward, Andrew B., Wilson, Ian A., Burton, Dennis R., Smith, Davey, Kosakovsky Pond, Sergei L., Poignard, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736302/
https://www.ncbi.nlm.nih.gov/pubmed/29166592
http://dx.doi.org/10.1016/j.immuni.2017.11.002

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