The CDK-PLK1 axis targets the DNA damage checkpoint sensor protein RAD9 to promote cell proliferation and tolerance to genotoxic stress

Genotoxic stress causes proliferating cells to activate the DNA damage checkpoint, to assist DNA damage recovery by slowing cell cycle progression. Thus, to drive proliferation, cells must tolerate DNA damage and suppress the checkpoint response. However, the mechanism underlying this negative regul...

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Detalles Bibliográficos
Autores principales: Wakida, Takeshi, Ikura, Masae, Kuriya, Kenji, Ito, Shinji, Shiroiwa, Yoshiharu, Habu, Toshiyuki, Kawamoto, Takuo, Okumura, Katsuzumi, Ikura, Tsuyoshi, Furuya, Kanji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736350/
https://www.ncbi.nlm.nih.gov/pubmed/29254517
http://dx.doi.org/10.7554/eLife.29953

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