Inducible and reversible phenotypes in a novel mouse model of Friedreich’s Ataxia

Friedreich's ataxia (FRDA), the most common inherited ataxia, is caused by recessive mutations that reduce the levels of frataxin (FXN), a mitochondrial iron binding protein. We developed an inducible mouse model of Fxn deficiency that enabled us to control the onset and progression of disease...

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Detalles Bibliográficos
Autores principales: Chandran, Vijayendran, Gao, Kun, Swarup, Vivek, Versano, Revital, Dong, Hongmei, Jordan, Maria C, Geschwind, Daniel H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736353/
https://www.ncbi.nlm.nih.gov/pubmed/29257745
http://dx.doi.org/10.7554/eLife.30054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736353/
https://www.ncbi.nlm.nih.gov/pubmed/29257745
http://dx.doi.org/10.7554/eLife.30054

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