Cargando…

The TGF-β System As a Potential Pathogenic Player in Disease Modulation of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) represents a fatal orphan disease with high unmet medical need, and a life time risk of approx. 1/400 persons per population. Based on increasing knowledge on pathophysiology including genetic and molecular changes, epigenetics, and immune dysfunction, inflammator...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peters, Sebastian, Zitzelsperger, Eva, Kuespert, Sabrina, Iberl, Sabine, Heydn, Rosmarie, Johannesen, Siw, Petri, Susanne, Aigner, Ludwig, Thal, Dietmar R., Hermann, Andreas, Weishaupt, Jochen H., Bruun, Tim-Henrik, Bogdahn, Ulrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736544/ https://www.ncbi.nlm.nih.gov/pubmed/29326641 http://dx.doi.org/10.3389/fneur.2017.00669

Ejemplares similares

Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2—A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling
por: Kuespert, Sabrina, et al.
Publicado: (2020)

Reconditioning the Neurogenic Niche of Adult Non-human Primates by Antisense Oligonucleotide-Mediated Attenuation of TGFβ Signaling
por: Peters, Sebastian, et al.
Publicado: (2021)

Safe and Effective Cynomolgus Monkey GLP—Tox Study with Repetitive Intrathecal Application of a TGFBR2 Targeting LNA-Gapmer Antisense Oligonucleotide as Treatment Candidate for Neurodegenerative Disorders
por: Peters, Sebastian, et al.
Publicado: (2022)

Direct Potential Modulation of Neurogenic Differentiation Markers by Granulocyte-Colony Stimulating Factor (G-CSF) in the Rodent Brain
por: Kozole, Judith, et al.
Publicado: (2022)

Modeling and Bioinformatics Identify Responders to G-CSF in Patients With Amyotrophic Lateral Sclerosis
por: Johannesen, Siw, et al.
Publicado: (2021)

Value of fluid‐attenuated inversion recovery MRI data analyzed by the lesion segmentation toolbox in amyotrophic lateral sclerosis
por: Wirth, Anna M., et al.
Publicado: (2018)

Biomarker Supervised G-CSF (Filgrastim) Response in ALS Patients
por: Johannesen, Siw, et al.
Publicado: (2018)

Combinatory Biomarker Use of Cortical Thickness, MUNIX, and ALSFRS-R at Baseline and in Longitudinal Courses of Individual Patients With Amyotrophic Lateral Sclerosis
por: Wirth, Anna M., et al.
Publicado: (2018)

TGF-β Signaling: A Therapeutic Target to Reinstate Regenerative Plasticity in Vascular Dementia?
por: Kandasamy, Mahesh, et al.
Publicado: (2020)

TGF-beta signalling in the adult neurogenic niche promotes stem cell quiescence as well as generation of new neurons
por: Kandasamy, Mahesh, et al.
Publicado: (2014)

Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis
por: Freischmidt, Axel, et al.
Publicado: (2013)

CCN2/CTGF tip the balance of growth factors towards TGF-β2 in primary open-angle glaucoma
por: Dillinger, Andrea E., et al.
Publicado: (2023)

Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche: A Therapeutic Target for Huntington's Disease
por: Kandasamy, Mahesh, et al.
Publicado: (2011)

Current knowledge and recent insights into the genetic basis of amyotrophic lateral sclerosis
por: Volk, Alexander E., et al.
Publicado: (2018)

Protease-resistant SOD1 aggregates in amyotrophic lateral sclerosis demonstrated by paraffin-embedded tissue (PET) blot
por: Steinacker, Petra, et al.
Publicado: (2014)

Age-dependent and differential effects of Smad7ΔEx1 on neural progenitor cell proliferation and on neurogenesis
por: Marschallinger, Julia, et al.
Publicado: (2014)

Localization of natriuretic peptide receptors A, B, and C in healthy and diseased mouse kidneys
por: Heinl, Elena-Sofia, et al.
Publicado: (2022)

Heterozygous DHTKD1 Variants in Two European Cohorts of Amyotrophic Lateral Sclerosis Patients
por: Osmanovic, Alma, et al.
Publicado: (2021)

Temporospatial Analysis and New Players in the Immunology of Amyotrophic Lateral Sclerosis
por: Iyer, Abhirami K., et al.
Publicado: (2018)

Degenerative and regenerative processes in amyotrophic lateral sclerosis: motor reserve, adaptation and putative compensatory changes
por: Bede, Peter, et al.
Publicado: (2020)

Profilin 1 with the amyotrophic lateral sclerosis associated mutation T109M displays unaltered actin binding and does not affect the actin cytoskeleton
por: Freischmidt, Axel, et al.
Publicado: (2015)

Respiratory onset of amyotrophic lateral sclerosis in a pregnant woman with a novel SOD1 mutation
por: Masrori, Pegah, et al.
Publicado: (2022)

Longitudinal Diffusion Tensor Imaging-Based Assessment of Tract Alterations: An Application to Amyotrophic Lateral Sclerosis
por: Baldaranov, Dobri, et al.
Publicado: (2017)

Interleukin-1 Antagonist Anakinra in Amyotrophic Lateral Sclerosis—A Pilot Study
por: Maier, André, et al.
Publicado: (2015)

Spectrum and frequency of genetic variants in sporadic amyotrophic lateral sclerosis
por: Ruf, Wolfgang P, et al.
Publicado: (2023)

Editorial: Cellular CNS repair strategies, technologies and therapeutic developments
por: Bruun, Tim-Henrik, et al.
Publicado: (2023)

Keratoconus in vitro and the key players of the TGF-β pathway
por: Priyadarsini, Shrestha, et al.
Publicado: (2015)

Human in vitro reporter model of neuronal development and early differentiation processes
por: Couillard-Despres, Sebastien, et al.
Publicado: (2008)

Phenotypes and malignancy risk of different FUS mutations in genetic amyotrophic lateral sclerosis
por: Naumann, Marcel, et al.
Publicado: (2019)

Telomere shortening leads to earlier age of onset in ALS mice
por: Linkus, Birgit, et al.
Publicado: (2016)

Skeletal Muscle MicroRNAs as Key Players in the Pathogenesis of Amyotrophic Lateral Sclerosis
por: Di Pietro, Lorena, et al.
Publicado: (2018)

The gut microbiome: a key player in the complexity of amyotrophic lateral sclerosis (ALS)
por: Boddy, Sarah L., et al.
Publicado: (2021)

Identification of a potential non-coding RNA biomarker signature for amyotrophic lateral sclerosis
por: Joilin, Greig, et al.
Publicado: (2020)

Widespread temporo-occipital lobe dysfunction in amyotrophic lateral sclerosis
por: Loewe, Kristian, et al.
Publicado: (2017)

Clearance of amyloid β-protein and its role in the spreading of Alzheimer's disease pathology
por: Thal, Dietmar R.
Publicado: (2015)

The Precapillary Segment of the Blood-Brain Barrier and Its Relation to Perivascular Drainage in Alzheimer's Disease and Small Vessel Disease.
por: Thal, Dietmar R.
Publicado: (2009)

A natural history comparison of SOD1-mutant patients with amyotrophic lateral sclerosis between Chinese and German populations
por: Tang, Lu, et al.
Publicado: (2021)

TDP-43 is intercellularly transmitted across axon terminals
por: Feiler, Marisa S., et al.
Publicado: (2015)

The Golgi-localized, gamma ear-containing, ARF-binding (GGA) protein family alters alpha synuclein (α-syn) oligomerization and secretion
por: von Einem, Bjoern, et al.
Publicado: (2017)

Magnetic Resonance Imaging in Amyotrophic Lateral Sclerosis
por: Kollewe, Katja, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_ji9jo8vp37do94hm53kblouno2