ATP-degrading ENPP1 is required for survival (or persistence) of long-lived plasma cells

Survival of antibody-secreting plasma cells (PCs) is vital for sustained antibody production. However, it remains poorly understood how long-lived PCs (LLPCs) are generated and maintained. Here we report that ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is preferentially upregulated in...

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Detalles Bibliográficos
Autores principales: Wang, Hongsheng, Gonzalez-Garcia, Ines, Traba, Javier, Jain, Shweta, Conteh, Solomon, Shin, Dong-Mi, Qi, Chenfeng, Gao, Yuanyuan, Sun, Jiafang, Kang, Sungyun, Abbasi, Sadia, Naghashfar, Zohreh, Yoon, Jeongheon, DuBois, Wendy, Kovalchuk, Alexander L., Sack, Michael N., Duffy, Patrick, Morse, Herbert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736562/
https://www.ncbi.nlm.nih.gov/pubmed/29259245
http://dx.doi.org/10.1038/s41598-017-18028-z

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