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Revisiting medial preoptic area plasticity induced in male mice by sexual experience
Sexual experience in male rodents, induced by a first exposure to a receptive female, improves efficiency of following copulations. In mice, the mechanisms supporting this improvement are poorly understood. We characterized molecular modifications of the mouse hypothalamic medial preoptic area (mPOA...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736590/ https://www.ncbi.nlm.nih.gov/pubmed/29259324 http://dx.doi.org/10.1038/s41598-017-18248-3 |
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author | Jean, Arnaud Bonnet, Pauline Liere, Philippe Mhaouty-Kodja, Sakina Hardin-Pouzet, Helene |
author_facet | Jean, Arnaud Bonnet, Pauline Liere, Philippe Mhaouty-Kodja, Sakina Hardin-Pouzet, Helene |
author_sort | Jean, Arnaud |
collection | PubMed |
description | Sexual experience in male rodents, induced by a first exposure to a receptive female, improves efficiency of following copulations. In mice, the mechanisms supporting this improvement are poorly understood. We characterized molecular modifications of the mouse hypothalamic medial preoptic area (mPOA), the main integrative structure for male sexual behaviour, after a single mating event. This paradigm induced long-lasting behavioural improvements and mPOA morphological changes, evidenced by dendritic spine maturation and an increase in the acetylated and tri-methylated forms of histone H3. Ejaculation affected testosterone, progesterone and corticosterone levels in both naive and experienced mice, but sexual experience did not modify basal plasma or hypothalamic levels of steroids. In contrast to studies carried out in rats, no changes were observed, either in the nitrergic system, or in sex steroid receptor levels. However, levels of glutamate- and calcium-associated proteins, including PSD-95, calbindin and the GluN1 subunit of the NMDA receptor, were increased in sexually experienced male mice. The Iba-1 microglial marker was up-regulated in these animals suggesting multicellular interactions induced within the mPOA by sexual experience. In conclusion, plasticity mechanisms induced by sexual experience differ between rat and mouse, even if in both cases they converge to potentiation of the mPOA network. |
format | Online Article Text |
id | pubmed-5736590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-57365902017-12-21 Revisiting medial preoptic area plasticity induced in male mice by sexual experience Jean, Arnaud Bonnet, Pauline Liere, Philippe Mhaouty-Kodja, Sakina Hardin-Pouzet, Helene Sci Rep Article Sexual experience in male rodents, induced by a first exposure to a receptive female, improves efficiency of following copulations. In mice, the mechanisms supporting this improvement are poorly understood. We characterized molecular modifications of the mouse hypothalamic medial preoptic area (mPOA), the main integrative structure for male sexual behaviour, after a single mating event. This paradigm induced long-lasting behavioural improvements and mPOA morphological changes, evidenced by dendritic spine maturation and an increase in the acetylated and tri-methylated forms of histone H3. Ejaculation affected testosterone, progesterone and corticosterone levels in both naive and experienced mice, but sexual experience did not modify basal plasma or hypothalamic levels of steroids. In contrast to studies carried out in rats, no changes were observed, either in the nitrergic system, or in sex steroid receptor levels. However, levels of glutamate- and calcium-associated proteins, including PSD-95, calbindin and the GluN1 subunit of the NMDA receptor, were increased in sexually experienced male mice. The Iba-1 microglial marker was up-regulated in these animals suggesting multicellular interactions induced within the mPOA by sexual experience. In conclusion, plasticity mechanisms induced by sexual experience differ between rat and mouse, even if in both cases they converge to potentiation of the mPOA network. Nature Publishing Group UK 2017-12-19 /pmc/articles/PMC5736590/ /pubmed/29259324 http://dx.doi.org/10.1038/s41598-017-18248-3 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Jean, Arnaud Bonnet, Pauline Liere, Philippe Mhaouty-Kodja, Sakina Hardin-Pouzet, Helene Revisiting medial preoptic area plasticity induced in male mice by sexual experience |
title | Revisiting medial preoptic area plasticity induced in male mice by sexual experience |
title_full | Revisiting medial preoptic area plasticity induced in male mice by sexual experience |
title_fullStr | Revisiting medial preoptic area plasticity induced in male mice by sexual experience |
title_full_unstemmed | Revisiting medial preoptic area plasticity induced in male mice by sexual experience |
title_short | Revisiting medial preoptic area plasticity induced in male mice by sexual experience |
title_sort | revisiting medial preoptic area plasticity induced in male mice by sexual experience |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736590/ https://www.ncbi.nlm.nih.gov/pubmed/29259324 http://dx.doi.org/10.1038/s41598-017-18248-3 |
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