Correction of a Disease Mutation using CRISPR/Cas9-assisted Genome Editing in Japanese Black Cattle

Isoleucyl-tRNA synthetase (IARS) syndrome is a recessive disease of Japanese Black cattle caused by a single nucleotide substitution. To repair the mutated IARS gene, we designed clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) to create a double-...

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Detalles Bibliográficos
Autores principales: Ikeda, Mitsumi, Matsuyama, Shuichi, Akagi, Satoshi, Ohkoshi, Katsuhiro, Nakamura, Sho, Minabe, Shiori, Kimura, Koji, Hosoe, Misa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736618/
https://www.ncbi.nlm.nih.gov/pubmed/29259316
http://dx.doi.org/10.1038/s41598-017-17968-w

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