Classification of gene signatures for their information value and functional redundancy

Gene signatures are more and more used to interpret results of omics data analyses but suffer from compositional (large overlap) and functional (correlated read-outs) redundancy. Moreover, many gene signatures rarely come out as significant in statistical tests. Based on pan-cancer data analysis, we...

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Detalles Bibliográficos
Autores principales: Cantini, Laura, Calzone, Laurence, Martignetti, Loredana, Rydenfelt, Mattias, Blüthgen, Nils, Barillot, Emmanuel, Zinovyev, Andrei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736638/
https://www.ncbi.nlm.nih.gov/pubmed/29263798
http://dx.doi.org/10.1038/s41540-017-0038-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736638/
https://www.ncbi.nlm.nih.gov/pubmed/29263798
http://dx.doi.org/10.1038/s41540-017-0038-8

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