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IFNγ induces PD-L1 overexpression by JAK2/STAT1/IRF-1 signaling in EBV-positive gastric carcinoma

Programmed death-ligand 1 (PD-L1) acts as an immune checkpoint inhibitor in various cancers. PD-L1 is known to be more frequently expressed in EBV (+) gastric cancer (GC). However, the mechanisms underlying the regulation of PD-L1 expression in EBV (+) GC remain unclear. We investigated the basal an...

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Detalles Bibliográficos
Autores principales:	Moon, Ji Wook, Kong, Su-Kang, Kim, Byung Soo, Kim, Hyun Ji, Lim, Hyangsoon, Noh, Kyeonga, Kim, Younghye, Choi, Jung-Woo, Lee, Ju-Han, Kim, Young-Sik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736657/ https://www.ncbi.nlm.nih.gov/pubmed/29259270 http://dx.doi.org/10.1038/s41598-017-18132-0

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