The malignant niche: safe spaces for toxic stem cell marketing

Many tumors are sustained by microenvironments, or niches, that support and protect malignant cells, thus conferring a competitive advantage against both healthy cells and therapeutic interventions (for a brief review, see Yao and Link (Stem Cells 35: 3–8, 2017)). The global industry engaged in the...

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Detalles Bibliográficos
Autor principal: Sipp, Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736713/
https://www.ncbi.nlm.nih.gov/pubmed/29302366
http://dx.doi.org/10.1038/s41536-017-0036-x
Descripción
Sumario:Many tumors are sustained by microenvironments, or niches, that support and protect malignant cells, thus conferring a competitive advantage against both healthy cells and therapeutic interventions (for a brief review, see Yao and Link (Stem Cells 35: 3–8, 2017)). The global industry engaged in the commercial promotion of unproven and scientifically implausible cell-based “regenerative” therapies has developed a number of self-protective strategies that support its survival and growth in ways that are broadly analogous to the functions of the malignant niche.

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