GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity

Glutathione transferase Omega 1 (GSTO1-1) is an atypical GST reported to play a pro-inflammatory role in response to LPS. Here we show that genetic knockout of Gsto1 alters the response of mice to three distinct inflammatory disease models. GSTO1-1 deficiency ameliorates the inflammatory response st...

Descripción completa

Detalles Bibliográficos
Autores principales: Menon, Deepthi, Innes, Ashlee, Oakley, Aaron J., Dahlstrom, Jane E., Jensen, Lora M., Brüstle, Anne, Tummala, Padmaja, Rooke, Melissa, Casarotto, Marco G., Baell, Jonathan B., Nguyen, Nghi, Xie, Yiyue, Cuellar, Matthew, Strasser, Jessica, Dahlin, Jayme L., Walters, Michael A., Burgio, Gaetan, O’Neill, Luke A. J., Board, Philip G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736720/
https://www.ncbi.nlm.nih.gov/pubmed/29259211
http://dx.doi.org/10.1038/s41598-017-17861-6

Ejemplares similares

Ejemplares similares