The Differential Absorption of a Series of P-Glycoprotein Substrates in Isolated Perfused Lungs from Mdr1a/1b Genetic Knockout Mice can be Attributed to Distinct Physico-Chemical Properties: an Insight into Predicting Transporter-Mediated, Pulmonary Specific Disposition

PURPOSE: To examine if pulmonary P-glycoprotein (P-gp) is functional in an intact lung; impeding the pulmonary absorption and increasing lung retention of P-gp substrates administered into the airways. Using calculated physico-chemical properties alone build a predictive Quantitative Structure-Activ...

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Detalles Bibliográficos
Autores principales: Price, Daniel F., Luscombe, Chris N., Eddershaw, Peter J., Edwards, Chris D., Gumbleton, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736782/
https://www.ncbi.nlm.nih.gov/pubmed/28702798
http://dx.doi.org/10.1007/s11095-017-2220-5

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