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Factor Xa inhibition by rivaroxaban in the trough steady state can significantly reduce thrombin generation

AIMS: The aim of the present study was to demonstrate evidence of reduced thrombin generation at the trough plasma rivaroxaban concentration. METHODS: A single‐centre, prospective, nonrandomized, drug‐intervention, self‐controlled study was conducted in 51 anticoagulation therapy‐naïve patients with...

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Detalles Bibliográficos
Autores principales:	Horinaka, Shigeo, Sugawara, Rie, Yonezawa, Yutaka, Ishimitsu, Toshihiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Pharmacokinetic Dynamic Relationships
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736851/ https://www.ncbi.nlm.nih.gov/pubmed/28888219 http://dx.doi.org/10.1111/bcp.13429

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