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Extracellular Matrix Bioscaffolds for Building Gastrointestinal Tissue

Regenerative medicine is a rapidly advancing field that uses principles of tissue engineering, developmental biology, stem cell biology, immunology, and bioengineering to reconstruct diseased or damaged tissues. Biologic scaffolds composed of extracellular matrix have shown great promise as an induc...

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Detalles Bibliográficos
Autores principales: Hussey, George S., Cramer, Madeline C., Badylak, Stephen F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736871/
https://www.ncbi.nlm.nih.gov/pubmed/29276748
http://dx.doi.org/10.1016/j.jcmgh.2017.09.004
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author Hussey, George S.
Cramer, Madeline C.
Badylak, Stephen F.
author_facet Hussey, George S.
Cramer, Madeline C.
Badylak, Stephen F.
author_sort Hussey, George S.
collection PubMed
description Regenerative medicine is a rapidly advancing field that uses principles of tissue engineering, developmental biology, stem cell biology, immunology, and bioengineering to reconstruct diseased or damaged tissues. Biologic scaffolds composed of extracellular matrix have shown great promise as an inductive substrate to facilitate the constructive remodeling of gastrointestinal (GI) tissue damaged by neoplasia, inflammatory bowel disease, and congenital or acquired defects. The present review summarizes the preparation and use of extracellular matrix scaffolds for bioengineering of the GI tract, identifies significant advances made in regenerative medicine for the reconstruction of functional GI tissue, and describes an emerging therapeutic approach.
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spelling pubmed-57368712017-12-22 Extracellular Matrix Bioscaffolds for Building Gastrointestinal Tissue Hussey, George S. Cramer, Madeline C. Badylak, Stephen F. Cell Mol Gastroenterol Hepatol Review Regenerative medicine is a rapidly advancing field that uses principles of tissue engineering, developmental biology, stem cell biology, immunology, and bioengineering to reconstruct diseased or damaged tissues. Biologic scaffolds composed of extracellular matrix have shown great promise as an inductive substrate to facilitate the constructive remodeling of gastrointestinal (GI) tissue damaged by neoplasia, inflammatory bowel disease, and congenital or acquired defects. The present review summarizes the preparation and use of extracellular matrix scaffolds for bioengineering of the GI tract, identifies significant advances made in regenerative medicine for the reconstruction of functional GI tissue, and describes an emerging therapeutic approach. Elsevier 2017-09-14 /pmc/articles/PMC5736871/ /pubmed/29276748 http://dx.doi.org/10.1016/j.jcmgh.2017.09.004 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Hussey, George S.
Cramer, Madeline C.
Badylak, Stephen F.
Extracellular Matrix Bioscaffolds for Building Gastrointestinal Tissue
title Extracellular Matrix Bioscaffolds for Building Gastrointestinal Tissue
title_full Extracellular Matrix Bioscaffolds for Building Gastrointestinal Tissue
title_fullStr Extracellular Matrix Bioscaffolds for Building Gastrointestinal Tissue
title_full_unstemmed Extracellular Matrix Bioscaffolds for Building Gastrointestinal Tissue
title_short Extracellular Matrix Bioscaffolds for Building Gastrointestinal Tissue
title_sort extracellular matrix bioscaffolds for building gastrointestinal tissue
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736871/
https://www.ncbi.nlm.nih.gov/pubmed/29276748
http://dx.doi.org/10.1016/j.jcmgh.2017.09.004
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