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Hepatoprotective and Antioxidant Effect of Mangifera Indica Leaf Extracts against Mercuric Chloride-induced Liver Toxicity in Mice

BACKGROUND: To explore the antioxidant and hepatoprotective effect of ethanolic Mangifera indica (EMI) and methanolic Mangifera indica (MMI) leaf extracts in mercuric chloride (HgCl(2)) induced toxicity in Swiss albino mice. MATERIALS AND METHODS: Toxicity in mice was induced with HgCl(2) (5.0 mg/kg...

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Autores principales: Karuppanan, Muthupillai, Krishnan, Manigandan, Padarthi, Pavankumar, Namasivayam, Elangovan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Jaypee Brothers Medical Publishers 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736951/
https://www.ncbi.nlm.nih.gov/pubmed/29264314
http://dx.doi.org/10.5005/jp-journals-10018-1091
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author Karuppanan, Muthupillai
Krishnan, Manigandan
Padarthi, Pavankumar
Namasivayam, Elangovan
author_facet Karuppanan, Muthupillai
Krishnan, Manigandan
Padarthi, Pavankumar
Namasivayam, Elangovan
author_sort Karuppanan, Muthupillai
collection PubMed
description BACKGROUND: To explore the antioxidant and hepatoprotective effect of ethanolic Mangifera indica (EMI) and methanolic Mangifera indica (MMI) leaf extracts in mercuric chloride (HgCl(2)) induced toxicity in Swiss albino mice. MATERIALS AND METHODS: Toxicity in mice was induced with HgCl(2) (5.0 mg/kg, i.p.), followed by oral intervention with EMI and MMI extracts (25 mg and 50 mg/kg. body wt.) for 30 days. RESULTS AND DISCUSSION: The extent of liver damage was assessed from the extents of histopathological, morphological, antioxidant and liver enzymes. Mercuric chloride-induced mice showed an increased cellular damage whereas leaf extracts of EMI and MMI-treated mice showed recovery of damaged hepatocytes. Mercuric chloride intoxicated mice exhibited a significant (p < 0.05) elevation in the liver enzymes (Aspartate amino transferase and Alanine amino transferase) and gradual decline in the cellular radical scavenging enzyme levels (Catalase, Glutathione-s-transferase and Glutathione peroxidase. The combined treatment with EMI and MMI leaf extracts significantly (p < 0.05) reversed these parameters. However, the effects of MMI leaf extract (50 mg/kg) were superior to those of EMI- treated mice possibly due to its potent radical scavenging property. These results suggest that oral supplementation of Mangifera indica extract remarkably reduces hepatotoxicity in mice possibly through its antioxidant potentials. How to cite this article: Karuppanan M, Krishnan M, Padarthi P, Namasivayam E. Hepatoprotec-tive and Antioxidant Effect of Mangifera Indica Leaf Extracts against Mercuric Chloride-induced Liver Toxicity in Mice. Euroasian J Hepato-Gastroenterol 2014;4(1):18-24.
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spelling pubmed-57369512017-12-20 Hepatoprotective and Antioxidant Effect of Mangifera Indica Leaf Extracts against Mercuric Chloride-induced Liver Toxicity in Mice Karuppanan, Muthupillai Krishnan, Manigandan Padarthi, Pavankumar Namasivayam, Elangovan Euroasian J Hepatogastroenterol Original Article BACKGROUND: To explore the antioxidant and hepatoprotective effect of ethanolic Mangifera indica (EMI) and methanolic Mangifera indica (MMI) leaf extracts in mercuric chloride (HgCl(2)) induced toxicity in Swiss albino mice. MATERIALS AND METHODS: Toxicity in mice was induced with HgCl(2) (5.0 mg/kg, i.p.), followed by oral intervention with EMI and MMI extracts (25 mg and 50 mg/kg. body wt.) for 30 days. RESULTS AND DISCUSSION: The extent of liver damage was assessed from the extents of histopathological, morphological, antioxidant and liver enzymes. Mercuric chloride-induced mice showed an increased cellular damage whereas leaf extracts of EMI and MMI-treated mice showed recovery of damaged hepatocytes. Mercuric chloride intoxicated mice exhibited a significant (p < 0.05) elevation in the liver enzymes (Aspartate amino transferase and Alanine amino transferase) and gradual decline in the cellular radical scavenging enzyme levels (Catalase, Glutathione-s-transferase and Glutathione peroxidase. The combined treatment with EMI and MMI leaf extracts significantly (p < 0.05) reversed these parameters. However, the effects of MMI leaf extract (50 mg/kg) were superior to those of EMI- treated mice possibly due to its potent radical scavenging property. These results suggest that oral supplementation of Mangifera indica extract remarkably reduces hepatotoxicity in mice possibly through its antioxidant potentials. How to cite this article: Karuppanan M, Krishnan M, Padarthi P, Namasivayam E. Hepatoprotec-tive and Antioxidant Effect of Mangifera Indica Leaf Extracts against Mercuric Chloride-induced Liver Toxicity in Mice. Euroasian J Hepato-Gastroenterol 2014;4(1):18-24. Jaypee Brothers Medical Publishers 2014 2014-01-22 /pmc/articles/PMC5736951/ /pubmed/29264314 http://dx.doi.org/10.5005/jp-journals-10018-1091 Text en Copyright © 2014; Jaypee Brothers Medical Publishers (P) Ltd. This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
spellingShingle Original Article
Karuppanan, Muthupillai
Krishnan, Manigandan
Padarthi, Pavankumar
Namasivayam, Elangovan
Hepatoprotective and Antioxidant Effect of Mangifera Indica Leaf Extracts against Mercuric Chloride-induced Liver Toxicity in Mice
title Hepatoprotective and Antioxidant Effect of Mangifera Indica Leaf Extracts against Mercuric Chloride-induced Liver Toxicity in Mice
title_full Hepatoprotective and Antioxidant Effect of Mangifera Indica Leaf Extracts against Mercuric Chloride-induced Liver Toxicity in Mice
title_fullStr Hepatoprotective and Antioxidant Effect of Mangifera Indica Leaf Extracts against Mercuric Chloride-induced Liver Toxicity in Mice
title_full_unstemmed Hepatoprotective and Antioxidant Effect of Mangifera Indica Leaf Extracts against Mercuric Chloride-induced Liver Toxicity in Mice
title_short Hepatoprotective and Antioxidant Effect of Mangifera Indica Leaf Extracts against Mercuric Chloride-induced Liver Toxicity in Mice
title_sort hepatoprotective and antioxidant effect of mangifera indica leaf extracts against mercuric chloride-induced liver toxicity in mice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736951/
https://www.ncbi.nlm.nih.gov/pubmed/29264314
http://dx.doi.org/10.5005/jp-journals-10018-1091
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