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The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer

We observed overexpression and increased intra-nuclear accumulation of the PRMT5/WDR77 in breast cancer cell lines relative to immortalized breast epithelial cells. Utilizing mass spectrometry and biochemistry approaches we identified the Zn-finger protein ZNF326, as a novel interaction partner and...

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Detalles Bibliográficos
Autores principales:	Rengasamy, Madhumitha, Zhang, Fan, Vashisht, Ajay, Song, Won-Min, Aguilo, Francesca, Sun, Yifei, Li, SiDe, Zhang, Weijia, Zhang, Bin, Wohlschlegel, James A., Walsh, Martin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737218/ https://www.ncbi.nlm.nih.gov/pubmed/28977470 http://dx.doi.org/10.1093/nar/gkx727

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